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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2004

Publications

Madigan, Victoria, Tyne O. Tyson, and Aravind Asokan. “Mass Spectrometric Identification of Host Factors that Restrict AAV Vector Genome Transcription.” In Molecular Therapy, 27:425–425. CELL PRESS, 2019.

Scholars@Duke

Castle, Michael J., Yuhsiang Cheng, Aravind Asokan, and Mark H. Tuszynski. “Physical Positioning Dramatically Improves Brain Transduction after Intrathecal Infusion of AAV9.” In Molecular Therapy, 27:97–98. CELL PRESS, 2019.

Scholars@Duke

Nelson, Christopher E., Yaoying Wu, Matthew P. Gemberling, Matthew L. Oliver, Matthew A. Waller, Joel D. Bohning, Jacqueline N. Robinson-Hamm, et al. “Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy..” Nat Med 25, no. 3 (March 2019): 427–32. https://doi.org/10.1038/s41591-019-0344-3.

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Mestre, Humberto, Lauren M. Hablitz, Anna Lr Xavier, Weixi Feng, Wenyan Zou, Tinglin Pu, Hiromu Monai, et al. “Aquaporin-4-dependent glymphatic solute transport in the rodent brain..” Elife 7 (December 18, 2018). https://doi.org/10.7554/eLife.40070.

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Meganck, Rita M., Erin K. Borchardt, Ruth M. Castellanos Rivera, Miranda L. Scalabrino, Jeremy E. Wilusz, William F. Marzluff, and Aravind Asokan. “Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo..” Mol Ther Nucleic Acids 13 (December 7, 2018): 89–98. https://doi.org/10.1016/j.omtn.2018.08.008.

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Castle, Michael J., Yuhsiang Cheng, Aravind Asokan, and Mark H. Tuszynski. “Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion..” Sci Adv 4, no. 11 (November 2018). https://doi.org/10.1126/sciadv.aau9859.

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Burwitz, Benjamin, Jochen Wettengel, Martin Muck-Hausl, Katherine Hammond, Marc Ringelhan, Chunkyu Ko, Jason Reed, et al. “A new HIV/HBV co-infection model: hepatocytic expression of human sodium taurocholate cotransporting polypeptide (NTCP) Enables Hepatitis B Virus Infection of Macaques.” In Journal of Medical Primatology, 47:324–324. WILEY, 2018.

Scholars@Duke

Tse, Longping V., Sven Moller-Tank, Rita M. Meganck, and Aravind Asokan. “Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses..” J Virol 92, no. 14 (July 15, 2018). https://doi.org/10.1128/JVI.00393-18.

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Albright, Blake H., Claire Storey, Garth Devlin, Mavis Agbandje-McKenna, and Aravind Asokan. “Capsid-Glycan Receptor Interactions Influence AAV Transport across the Blood-Brain Barrier.” In Molecular Therapy, 26:29–29. CELL PRESS, 2018.

Scholars@Duke

Robinson-Hamm, Jacqueline N., Christopher E. Nelson, Matthew Gemberling, Veronica Gough, Ruth M Castellanos Rivera, Annemieke Aartsma-Rus, Aravind Asokan, and Charles A. Gersbach. “Dystrophin Restoration in a Humanized Mouse Model of Duchenne Muscular Dystrophy by Gene Editing with S. Aureus Cas9.” In Molecular Therapy, 26:118–19. CELL PRESS, 2018.

Scholars@Duke

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