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Aravind Asokan, PhD

Instructor in the Department of Surgery
Campus Mail: DUMC 203 Research Drive, MSRB1 Room 481A, Box 2653, Duke Surgery, Durham, NC 27710

Research Interests

  • Virology
  • RNA Biology
  • Viral Engineering
  • RNA Engineering
  • Gene Therapy
  • Gene Editing
  • Gene Regulation
  • Regenerative Medicine

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2004

Publications

Castle, MJ, Cheng, Y, Asokan, A, and Tuszynski, MH. "Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion." Science Advances 4, no. 11 (November 14, 2018): eaau9859-null.

Full Text

Burwitz, B, Wettengel, J, Muck-Hausl, M, Hammond, K, Ringelhan, M, Ko, C, Reed, J, Norris, R, Park, B, Moller-Tank, S, Esser, K, Greenel, J, Wu, H, Abdulhaqq, S, Webb, G, Sutton, W, Klug, A, Swanson, T, Legasse, A, Asokan, A, Haigwood, N, Protzer', U, and Sacha, J. "A new HIV/HBV co-infection model: hepatocytic expression of human sodium taurocholate cotransporting polypeptide (NTCP) Enables Hepatitis B Virus Infection of Macaques.": WILEY, October 1, 2018.

Scholars@Duke

Burwitz, B, Wettengel, J, Muck-Hausl, M, Hammond, K, Ringelhan, M, Ko, C, Reed, J, Norris, R, Park, B, Moller-Tank, S, Esser, K, Greenel, J, Wu, H, Abdulhaqq, S, Webb, G, Sutton, W, Klug, A, Swanson, T, Legasse, A, Asokan, A, Haigwood, N, Protzer', U, and Sacha, J. "A new HIV/HBV co-infection model: hepatocytic expression of human sodium taurocholate cotransporting polypeptide (NTCP) Enables Hepatitis B Virus Infection of Macaques.": WILEY, October 1, 2018.

Scholars@Duke

Meganck, RM, Borchardt, EK, Castellanos Rivera, RM, Scalabrino, ML, Wilusz, JE, Marzluff, WF, and Asokan, A. "Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo." Molecular Therapy. Nucleic Acids 13 (August 18, 2018): 89-98.

Full Text

Tse, LV, Moller-Tank, S, Meganck, RM, and Asokan, A. "Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses." Journal of Virology 92, no. 14 (July 2018).

Full Text

Albright, BH, Storey, C, Devlin, G, Agbandje-McKenna, M, and Asokan, A. "Capsid-Glycan Receptor Interactions Influence AAV Transport across the Blood-Brain Barrier." 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT). Chicago, IL. May 16, 2018 - May 19, 2018.: CELL PRESS, May 1, 2018.

Scholars@Duke

Robinson-Hamm, JN, Nelson, CE, Gemberling, M, Gough, V, Rivera, RMC, Aartsma-Rus, A, Asokan, A, and Gersbach, CA. "Dystrophin Restoration in a Humanized Mouse Model of Duchenne Muscular Dystrophy by Gene Editing with S. Aureus Cas9." 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT). Chicago, IL. May 16, 2018 - May 19, 2018.: CELL PRESS, May 1, 2018.

Scholars@Duke

Nelson, C, Gemberling, M, Oliver, ML, Hakim, CH, Rivera, RMC, Asokan, A, Duan, D, and Gersbach, CA. "Long-Term Evaluation of Genome Editing Outcomes for Duchenne Muscular Dystrophy." 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT). Chicago, IL. May 16, 2018 - May 19, 2018.: CELL PRESS, May 1, 2018.

Scholars@Duke

Tse, LV, Moller-Tank, S, Meganck, RM, Agbandje-McKenna, M, and Asokan, A. "Mapping and Engineering Functional Domains of the Assembly Activating Protein of Adeno-Associated Viruses." 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT). Chicago, IL. May 16, 2018 - May 19, 2018.: CELL PRESS, May 1, 2018.

Scholars@Duke

Madigan, VJ, Yuziuk, J, Tse, LV, Chiarella, A, Tyson, T, Hathaway, N, and Asokan, A. "RNF121 is a Key Transcriptional Regulator of AAV Genome Expression." 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT). Chicago, IL. May 16, 2018 - May 19, 2018.: CELL PRESS, May 1, 2018.

Scholars@Duke

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