Synthetic Virology & Gene Therapy
Meganck, Rita M., Jiacheng Liu, Andrew E. Hale, Katherine E. Simon, Marco M. Fanous, Heather A. Vincent, Jeremy E. Wilusz, Nathaniel J. Moorman, William F. Marzluff, and Aravind Asokan. “Engineering highly efficient backsplicing and translation of synthetic circRNAs.” Mol Ther Nucleic Acids 23 (March 5, 2021): 821–34. https://doi.org/10.1016/j.omtn.2021.01.003.
Cannon, Paula, Aravind Asokan, Agnieszka Czechowicz, Paula Hammond, Donald B. Kohn, Andre Lieber, Punam Malik, et al. “Safe and Effective In Vivo Targeting and Gene Editing in Hematopoietic Stem Cells: Strategies for Accelerating Development.” Hum Gene Ther 32, no. 1–2 (January 2021): 31–42. https://doi.org/10.1089/hum.2020.263.
Kwon, Jennifer B., Adarsh R. Ettyreddy, Ashish Vankara, Joel D. Bohning, Garth Devlin, Stephen D. Hauschka, Aravind Asokan, and Charles A. Gersbach. “In Vivo Gene Editing of Muscle Stem Cells with Adeno-Associated Viral Vectors in a Mouse Model of Duchenne Muscular Dystrophy.” Mol Ther Methods Clin Dev 19 (December 11, 2020): 320–29. https://doi.org/10.1016/j.omtm.2020.09.016.
Kang, Martin H., Jiabiao Hu, Richard E. Pratt, Conrad P. Hodgkinson, Aravind Asokan, and Victor J. Dzau. “Optimizing delivery for efficient cardiac reprogramming.” Biochem Biophys Res Commun 533, no. 1 (November 26, 2020): 9–16. https://doi.org/10.1016/j.bbrc.2020.08.104.
Madigan, Victoria J., Garrett E. Berry, Tyne O. Tyson, Dasean Nardone-White, Jonathan Ark, Zachary C. Elmore, Giridhar Murlidharan, Heather A. Vincent, and Aravind Asokan. “The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction.” J Virol 94, no. 21 (October 14, 2020). https://doi.org/10.1128/JVI.01604-20.
Elmore, Zachary C., Daniel K. Oh, Katherine E. Simon, Marco M. Fanous, and Aravind Asokan. “Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme.” Jci Insight 5, no. 19 (September 17, 2020). https://doi.org/10.1172/jci.insight.139881.
Havlik, L Patrick, Katherine E. Simon, J Kennon Smith, Kelli A. Klinc, Longping V. Tse, Daniel K. Oh, Marco M. Fanous, et al. “Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach.” J Virol 94, no. 19 (September 15, 2020). https://doi.org/10.1128/JVI.00976-20.
Das, Anshuman, Rodell Barrientos, Tomoyuki Shiota, Victoria Madigan, Ichiro Misumi, Kevin L. McKnight, Lu Sun, et al. “Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus.” Nat Microbiol 5, no. 9 (September 2020): 1069–78. https://doi.org/10.1038/s41564-020-0727-8.
Li, Jixue, Yanjie Li, Jun Wang, Trevor J. Gonzalez, Aravind Asokan, Jill S. Napierala, and Marek Napierala. “Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy.” Hum Gene Ther 31, no. 15–16 (August 2020): 839–51. https://doi.org/10.1089/hum.2020.053.
Elmore, Zachary, Daniel Oh, Katherine Simon, Marco Fanous, and Aravind Asokan. “A Novel Approach for Rapid and Transient Depletion of Pre-Existing Neutralizing Antibodies Against AAV Vectors.” In Molecular Therapy, 28:398–398, 2020.