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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2004

Publications

Madigan, Victoria J., Tyne O. Tyson, Julianne A. Yuziuk, Minakshi Pillai, Sven Moller-Tank, and Aravind Asokan. “A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes..” J Virol 93, no. 21 (November 1, 2019). https://doi.org/10.1128/JVI.00943-19.

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Abdulhaqq, Shaheed A., Helen Wu, John B. Schell, Katherine B. Hammond, Jason S. Reed, Alfred W. Legasse, Michael K. Axthelm, et al. “Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates..” J Virol 93, no. 19 (October 1, 2019). https://doi.org/10.1128/JVI.00592-19.

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Madigan, Victoria J., Julianne A. Yuziuk, Anna M. Chiarella, Tyne O. Tyson, Rita M. Meganck, Zachary C. Elmore, Longping V. Tse, Nathaniel A. Hathaway, and Aravind Asokan. “Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription..” Plos Pathog 15, no. 8 (August 2019). https://doi.org/10.1371/journal.ppat.1007988.

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Albright, Blake H., Katherine E. Simon, Minakshi Pillai, Garth W. Devlin, and Aravind Asokan. “Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses..” J Virol 93, no. 11 (June 1, 2019). https://doi.org/10.1128/JVI.00332-19.

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Madigan, Victoria, Tyne O. Tyson, Julianne A. Yuziuk, Minakshi Pillai, Sven Moller-Tank, and Aravind Asokan. “A CRISPR Screen Identifies Apical Polarity Determinant Crumbs 3 as an AAV Host Restriction Factor.” In Molecular Therapy, 27:424–25. CELL PRESS, 2019.

Scholars@Duke

Bulaklak, Karen, Jacqueline Robinson-Hamm, Veronica Gough, Christopher E. Nelson, Victoria Madigan, Aravind Asokan, and Charles A. Gersbach. “AAV-Mediated Deletion of a Large Mutational Hotspot for Treatment of Duchenne Muscular Dystrophy.” In Molecular Therapy, 27:377–377. CELL PRESS, 2019.

Scholars@Duke

Gonzalez, Trevor J., Rita Meganck, Marco Fanous, Kate Simon, and Aravind Asokan. “Design Principles for AAV Mediated Circular RNA Expression in the Brain.” In Molecular Therapy, 27:60–60. CELL PRESS, 2019.

Scholars@Duke

Havlik, L Patrick, L Victor Tse, J Kennon Smith, Kelli A. Klinc, Daniel Oh, Katherine Simon, Wenwei Shao, Chengwen Li, Mavis Agbandje-McKenna, and Aravind Asokan. “Engineering A Humanized AAV8 Capsid through Iterative Structure-Guided Evolution.” In Molecular Therapy, 27:53–53. CELL PRESS, 2019.

Scholars@Duke

Nelson, Christopher, Yaoying Wu, Matthew Gemberling, Matthew Oliver, Joel D. Bohning, Jacqueline N. Robinson-Hamm, Karen Bulaklak, et al. “Long-Term Evaluation of AAV-CRISPR Genome Editing for Duchenne Muscular Dystrophy.” In Molecular Therapy, 27:46–47. CELL PRESS, 2019.

Scholars@Duke

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