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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina - Chapel Hill, 2004

Publications

Elmore, Zachary C., Daniel K. Oh, Katherine E. Simon, Marco M. Fanous, and Aravind Asokan. “Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme.” Jci Insight 5, no. 19 (September 17, 2020). https://doi.org/10.1172/jci.insight.139881.

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Havlik, L Patrick, Katherine E. Simon, J Kennon Smith, Kelli A. Klinc, Longping V. Tse, Daniel K. Oh, Marco M. Fanous, et al. “Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach.” J Virol 94, no. 19 (September 15, 2020). https://doi.org/10.1128/JVI.00976-20.

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Kang, Martin H., Jiabiao Hu, Richard E. Pratt, Conrad P. Hodgkinson, Aravind Asokan, and Victor J. Dzau. “Optimizing delivery for efficient cardiac reprogramming.” Biochem Biophys Res Commun, September 8, 2020. https://doi.org/10.1016/j.bbrc.2020.08.104.

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Das, Anshuman, Rodell Barrientos, Tomoyuki Shiota, Victoria Madigan, Ichiro Misumi, Kevin L. McKnight, Lu Sun, et al. “Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus.” Nat Microbiol 5, no. 9 (September 2020): 1069–78. https://doi.org/10.1038/s41564-020-0727-8.

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Madigan, Victoria J., Garrett E. Berry, Tyne O. Tyson, Dasean Nardone-White, Jonathan Ark, Zachary C. Elmore, Giridhar Murlidharan, Heather A. Vincent, and Aravind Asokan. “The Golgi calcium ATPase pump plays an essential role in AAV trafficking and transduction.” J Virol, August 19, 2020. https://doi.org/10.1128/JVI.01604-20.

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Li, Jixue, Yanjie Li, Jun Wang, Trevor J. Gonzalez, Aravind Asokan, Jill S. Napierala, and Marek Napierala. “Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy.” Hum Gene Ther 31, no. 15–16 (August 2020): 839–51. https://doi.org/10.1089/hum.2020.053.

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Elmore, Zachary, Daniel Oh, Katherine Simon, Marco Fanous, and Aravind Asokan. “A Novel Approach for Rapid and Transient Depletion of Pre-Existing Neutralizing Antibodies Against AAV Vectors.” In Molecular Therapy, 28:398–398, 2020.

Scholars@Duke

McCall, Angela L., Augusto de Leon, Anna F. Fusco, Aidan Bailey, Marco Fanous, Aravind Asokan, and Mai K. ElMallah. “A Novel Capsid for Smooth Muscle Pathology in Pompe Disease.” In Molecular Therapy, 28:492–492, 2020.

Scholars@Duke

Gonzalez, Trevor J., L Patrick Havlik, Marco Fanous, Katherine Simon, Laura Edwards, Jennifer Kwon, V Grace Stafford, et al. “Cross-Species Evolution of Synthetic AAV Strains for Clinical Translation.” In Molecular Therapy, 28:12–13, 2020.

Scholars@Duke

Meganck, Rita M., Trevor J. Gonzalez, Heather A. Vincent, and Aravind Asokan. “Engineering Backsplicing Introns for Robust Expression of Synthetic Circular RNAs from AAV Vectors.” In Molecular Therapy, 28:21–21, 2020.

Scholars@Duke

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