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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Biomedical Engineering
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 103051, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina - Chapel Hill, 2004

Publications

Das, Anshuman, Madhuvanthi Vijayan, Eric M. Walton, V Grace Stafford, David N. Fiflis, and Aravind Asokan. “Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex.” J Virol 96, no. 4 (February 23, 2022): e0203921. https://doi.org/10.1128/JVI.02039-21.

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Emmanuel, Shanan N., J Kennon Smith, Jane Hsi, Yu-Shan Tseng, Matias Kaplan, Mario Mietzsch, Paul Chipman, Aravind Asokan, Robert McKenna, and Mavis Agbandje-McKenna. “Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants.” J Virol 96, no. 3 (February 9, 2022): e0125121. https://doi.org/10.1128/JVI.01251-21.

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Kesseli, Samuel, Madison Krischak, Qimeng Gao, Samantha Halpern, Min Zhang, Nader Abraham, Riley Kahan, et al. “Adeno-associated virus 9 mediates gene transduction during static cold storage in rodent liver transplantation.” In American Journal of Transplantation, 22:67–67, 2022.

Scholars@Duke

Vekstein, Andrew M., David C. Wendell, Sophia DeLuca, Ruorong Yan, Yifan Chen, Muath Bishawi, Garth W. Devlin, et al. “Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.” Front Cardiovasc Med 9 (2022): 833335. https://doi.org/10.3389/fcvm.2022.833335.

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Vekstein, Andrew M., David C. Wendell, Dawn E. Bowles, Sophia DeLuca, Ruorong Yan, Muath Bishawi, Garth Devlin, et al. “Targeted Intra-Coronary Delivery versus Intra-Myocardial Injection of Therapeutics for Myocardial Recovery: A Nanoparticle Image Guided Porcine Study.” In Circulation, Vol. 144, 2021.

Scholars@Duke

Pickar-Oliver, Adrian, Veronica Gough, Joel D. Bohning, Siyan Liu, Jacqueline N. Robinson-Hamm, Heather Daniels, William H. Majoros, Garth Devlin, Aravind Asokan, and Charles A. Gersbach. “Full-length dystrophin restoration via targeted exon integration by AAV-CRISPR in a humanized mouse model of Duchenne muscular dystrophy.” Mol Ther 29, no. 11 (November 3, 2021): 3243–57. https://doi.org/10.1016/j.ymthe.2021.09.003.

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Elmore, Zachary C., L. Patrick Havlik, Daniel K. Oh, Leif Anderson, George Daaboul, Garth W. Devlin, Heather A. Vincent, and Aravind Asokan. “The membrane associated accessory protein is an adeno-associated viral egress factor.” Nat Commun 12, no. 1 (October 29, 2021): 6239. https://doi.org/10.1038/s41467-021-26485-4.

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Havlik, L Patrick, Anshuman Das, Mario Mietzsch, Daniel K. Oh, Jonathan Ark, Robert McKenna, Mavis Agbandje-McKenna, and Aravind Asokan. “Receptor Switching in Newly Evolved Adeno-associated Viruses.” J Virol 95, no. 19 (September 9, 2021): e0058721. https://doi.org/10.1128/JVI.00587-21.

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Gemberling, Matthew P., Keith Siklenka, Erica Rodriguez, Katherine R. Tonn-Eisinger, Alejandro Barrera, Fang Liu, Ariel Kantor, et al. “Transgenic mice for in vivo epigenome editing with CRISPR-based systems.” Nat Methods 18, no. 8 (August 2021): 965–74. https://doi.org/10.1038/s41592-021-01207-2.

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Gibson, Rebecca A., Jeong-A Lim, Su Jin Choi, Leticia Flores, Lani Clinton, Deeksha Bali, Sarah Young, Aravind Asokan, Baodong Sun, and Priya S. Kishnani. “Characterization of liver GSD IX γ2 pathophysiology in a novel Phkg2-/- mouse model.” In Mol Genet Metab, 133:269–76, 2021. https://doi.org/10.1016/j.ymgme.2021.05.008.

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