Duke Surgery Division of Surgical Oncology’s Laura Rosenberger, MD, MS, Associate Professor of Surgery, has been selected for the U-01 award from the Department of Health and Human Services Food and Drug Administration for her research project titled “Defining Actional Opportunities in Malignant Phyllodes via Genomic Profiling.”
The U-01 award will fund $1.5 million to Dr. Rosenberger’s research project for 3 years. The project will allow a multi-site collaboration of tissue and data from Duke, Memorial Sloan Kettering Cancer Center (MSKCC), and Dana-Farber Brigham Cancer Center (DF-BCC). They can combine cases of this rare and aggressive tumor to identify potential therapeutic targets and develop a predictive model of recurrence events.
“Malignant phyllodes tumors are aggressive breast neoplasms, which have a disproportionately high local recurrence and metastatic rates, and afflict very young women,” says Dr. Rosenberger. “This research will provide an improved ability to predict the risk of recurrence and define clinically actionable opportunities for this rare, but frequently fatal, tumor.”
Dr. Rosenberger’s Research Team
Collaborators:
- Fresia Pareja, MD, PhD, MSKCC
- Stuart Schnitt, MD, DF-BCC
Key Personnel
- Edi Brogi, MD, PhD, MSKCC
- Aimee Crago, MD, PhD, MSKCC
- Rachel Factor, MD, Duke
- Juneko Grilley-Olson, MD, Duke
- Tari King, MD, DF-BCC
- Giacomo Montagna, MD, MPH, MSKCC
- Chandrajit Raut, MD, MSc, DF-BCC
- John Strickler, MD, Duke
- Samantha Thomas, Duke