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Duke University Urinary Dysfunction Laboratory

Photo of J Todd Purves, MD, PhD

J Todd Purves, MD, PhD

Campus Mail: DUMC Box 38321, Durham, NC 27710
Phone: 919-613-5918

Scientific Focus

Our lab focuses on projects that have direct relevance to disorders that are regularly encountered by practicing urologists in the clinic. We are particularly interested in benign urologic disease caused by inflammation in the bladder. We have shown that nod-like receptors (NLRs) and the inflammasomes they form are present in the bladder epithelia where they serve as sensors of sterile damage and potentially bacterial infection. Upon activation, these structures mature the pro-inflammatory cytokines IL-1β and IL-18, which are released and trigger inflammation and lower urinary tract symptoms, such as increased voiding frequency.

Inflammasome formation/activation during bladder outlet obstruction (such as during benign prostatic hyperplasia or BPH) and diabetes appears to be a major contributor to urinary dysfunction in those patient populations. Consequently, these two disorders are intensely under study in our lab. A thorough understanding of the inflammasome system in the bladder, while learning to manipulate this system for therapeutic advantage, is the main pillar of our lab.

Contact Us

Individuals interested in discussing this research and/or establishing collaborations should contact Dr. Todd Purves (todd.purves@duke.edu) or Dr. Monty Hughes (monty.hughes@duke.edu).

Latest Publications

Inouye, Brian M., Zachary R. Dionise, Ruiyang Jiang, Steven Wolf, Leigh Nicholl, Gina-Maria Pomann, John S. Wiener, J Todd Purves, and Jonathan C. Routh. “National Imaging and Antibiotic Practice Patterns in Children Presenting With Urinary Tract Infection to Community Practices: Little Impact From the American Academy of Pediatrics Guidelines?.” Clin Pediatr (Phila) 58, no. 11–12 (October 2019): 1302–8. https://doi.org/10.1177/0009922819853003.

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Kasotakis, George, Ekaterina Kintsurashvili, Manuel D. Galvan, Christopher Graham, J Todd Purves, Suresh Agarwal, David L. Corcoran, Bruce A. Sullenger, Scott M. Palmer, and Daniel G. Remick. “Histone Deacetylase 7 In Murine Gram-Negative Acute Lung Injury..” Shock, August 6, 2019. https://doi.org/10.1097/SHK.0000000000001431.

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Inouye, Brian M., Ruiyang Jiang, M Hassan Alkazemi, Hsin-Hsiao S. Wang, Steven Wolf, Gina-Maria Pomann, Rohit Tejwani, John S. Wiener, J Todd Purves, and Jonathan C. Routh. “Hospital and ED charges for spina bifida care in the United States between 2006 and 2014: Over $2 billion annually..” Disabil Health J 12, no. 3 (July 2019): 431–36. https://doi.org/10.1016/j.dhjo.2019.01.007.

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Dionise, Zachary R., Juan Marcos Gonzalez, Michael L. Garcia-Roig, Andrew J. Kirsch, Charles D. Scales, John S. Wiener, J Todd Purves, and Jonathan C. Routh. “Parental Preferences for Vesicoureteral Reflux Treatment: A Crowd-sourced, Best-worst Scaling Study..” Urology 128 (June 2019): 71–77. https://doi.org/10.1016/j.urology.2019.01.045.

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