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RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.

The first clinical studies utilizing RNA-guided endonucleases (RGENs) to therapeutically edit RNA and DNA in cancer patients were recently published. These groundbreaking technological advances promise to revolutionize genetic therapy and, as I discuss, represent the culmination of decades of innovative work to engineer RGENs for such editing applications.

Citation: 

Sullenger, Bruce A. “RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.” Cell 181, no. 5 (May 28, 2020): 955–60. https://doi.org/10.1016/j.cell.2020.04.050.

Published Date: 
Thursday, May 28, 2020
Published In: 
Cell
PMID: 
32470403