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Population coding in the cerebellum

January 19, 2021 - 12:00pm to 1:00pm
Reza Shadmehr, hosted by Court Hull

Duke Neurobiology welcomes Reza Shadmehr, PhD, Professor of Biomedical Engineering and of Neuroscience at Johns Hopkins University. Please email d.shipman@duke.edu for connection details. Abstract: How does one organize activities of neurons into populations? In the cerebral cortex, the current approach is to apply techniques that rely on similarity in the activities of the neurons, such as principal component analysis. In the cerebellum, however, it is possible to take a different approach, one that relies on anatomy and requirements of machine learning. Here, I consider the activity of Purkinje cells of the cerebellum in macaques and marmosets during saccadic eye movements. I suggest that Purkinje cells may be organized by the inferior olive into populations that share a preference for error. This error-based organization of cells into a population may describe population coding in the cerebellum.