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Brain Organoids and Next Generation Self-Organizing Models to Study Development and Disease

November 10, 2020 - 12:00pm to 1:00pm
Sergiu P. Pasca, MD, hosted by William Wetsel

Sergiu P. Pasca, MD (Stanford) will present "Brain Organoids and Next Generation Self-Organizing Models to Study Development and Disease" on Zoom. Contact d.shipman@duke.edu for connection details.
Research interests: Functional Human Brain Models of Disease.
A critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation. Our lab is using pluripotent stem cells (iPS cells) derived non-invasively from individuals to generate in a dish specific regions of the human brain in a functional 3D preparation we have developed. We are using months-to-years long 'brain-a-dish' cultures (also known as brain region-specific organoids or spheroids) to understand how neurons find their final position in the brain and how they mature functionally.