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Todd Victor Brennan, MD, MS

Associate Professor of Surgery
Office: 330 Trent Dr, Box 3512, Durham, NC 27710

Regulation of T Cell Subsets by Innate Immune Signals
The context in which antigen is encountered has a critical role in the regulation of the immune response. In the setting of tissue destruction and inflammation, the immune system is alerted to the presence of danger and mounts a stronger immune reaction. During organ transplantation, both the recipient tissues and the graft tissues suffer injury and release endogenous molecules that can act as potent stimulators of the innate immune response. With the discovery of Toll-like receptors (TLRs), which recognize molecules associated with tissue injury and infection, there has been increasing interest in the role of the innate immune system in the regulation of the adaptive immune system. The goal of our laboratory is to understand the contribution of innate pathway stimulation on the allospecific T cell response during organ transplantation. Through these studies, we aim to gain new insights into the molecular basis of alloimmunity and immune tolerance in order to reveal novel targets for the prevention and treatment of transplant rejection.

Education and Training

  • M.D., Harvard University, 1999
  • M.S., University of California at Los Angeles, 1994

Publications

Xu, H, Bendersky, VA, Brennan, TV, Espinosa, JR, and Kirk, AD. "IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (November 14, 2017).

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Brennan, TV, and Yang, Y. "PD-L1 serves as a double agent in separating GVL from GVHD." The Journal of clinical investigation 127, no. 5 (May 2017): 1627-1630.

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Chung, J, Ebens, CL, Perkey, E, Radojcic, V, Koch, U, Scarpellino, L, Tong, A, Allen, F, Wood, S, Feng, J, Friedman, A, Granadier, D, Tran, IT, Chai, Q, Onder, L, Yan, M, Reddy, P, Blazar, BR, Huang, AY, Brennan, TV, Bishop, DK, Ludewig, B, Siebel, CW, Radtke, F, Luther, SA, and Maillard, I. "Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands." The Journal of clinical investigation 127, no. 4 (April 2017): 1574-1588.

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Bracamonte-Baran, W, Florentin, J, Zhou, Y, Jankowska-Gan, E, Haynes, WJ, Zhong, W, Brennan, TV, Dutta, P, Claas, FHJ, van Rood, JJ, and Burlingham, WJ. "Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance." Proceedings of the National Academy of Sciences of the United States of America 114, no. 5 (January 17, 2017): 1099-1104.

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Brennan, TV, Lin, L, Brandstadter, JD, Rendell, VR, Dredge, K, Huang, X, and Yang, Y. "Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation." The Journal of clinical investigation 126, no. 1 (January 2016): 207-219.

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Brennan, TV, Rendell, VR, and Yang, Y. "Innate immune activation by tissue injury and cell death in the setting of hematopoietic stem cell transplantation." Frontiers in Immunology 6 (January 2015): 101-. (Review)

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Brennan, TV, Lunsford, KE, Vagefi, PA, Bostrom, A, Ma, M, and Feng, S. "Renal outcomes of simultaneous liver-kidney transplantation compared to liver transplant alone for candidates with renal dysfunction." Clinical transplantation 29, no. 1 (January 2015): 34-43.

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Rendell, VR, Giamberardino, C, Li, J, Markert, ML, and Brennan, TV. "Complete thymectomy in adult rats with non-invasive endotracheal intubation." Journal of visualized experiments : JoVE, no. 94 (December 29, 2014).

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Rege, AS, Rendell, VR, Shrimal, A, Engstrom, BI, Miller, MJ, Bashir, MR, and Brennan, TV. "May-Thurner syndrome complicating left-sided donor nephrectomy." Transplantation 97, no. 7 (April 2014): e40-e41. (Letter)

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Tripuraneni, V, Patel, K, Brennan, TV, and Ho, LM. "Fulminant herpes simplex viral hepatitis: ultrasound and CT imaging appearance and a review of the imaging literature." Clin Imaging 38, no. 2 (March 2014): 191-194.

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