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John S Yi, PhD

Assistant Professor of Surgery
Office: 915 S. Lasalle Street, 204 Sorf (Bldg. 41) Box 2926, Durham, NC 27710

I am an immunologist, with a focus to characterize the immune system in response to infectious and non-infectious diseases including cancer, HIV, autoimmune disease, and transplantation. My goals are to identify novel biomarkers/immune signatures that clinicians can utilize to diagnosis, predict disease outcomes, and determine patients' response to treatment. 

Education and Training

  • Ph.D., University of Alabama Birmingham, 2010


Michalek, Ryan D., Kimberly J. Nelson, Beth C. Holbrook, John S. Yi, Daya Stridiron, Larry W. Daniel, Jacquelyn S. Fetrow, S Bruce King, Leslie B. Poole, and Jason M. Grayson. “The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.” J Immunol 179, no. 10 (November 15, 2007): 6456–67.

Full Text

Michalek, Ryan D., Kimberly J. Nelson, John S. Yi, Daya Stridiron, S Bruce King, Leslie B. Poole, and Jason M. Grayson. “The Requirement of Reversible Cysteine Sulfenic Acid Formation in T Cell Activation and Function.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.


Yi, John S., Beth C. Holbrook, Ryan D. Michalek, Nathan G. Laniewski, and Jason M. Grayson. “Electron transport complex I is required for CD8+ T cell function.” J Immunol 177, no. 2 (July 15, 2006): 852–62.

Full Text

Yi, J. S. “The Rise of Checkpoint Blockade Therapy to Front Line Cancer Therapy.” Edited by A. H. Lichtman. Translational Immunology Update, n.d.