Skip to main content

John S Yi, PhD

Assistant Professor of Surgery
Office: 915 S. Lasalle Street, 204 Sorf (Bldg. 41) Box 2926, Durham, NC 27710

I am an immunologist, with a focus to characterize the immune system in response to infectious and non-infectious diseases including cancer, HIV, autoimmune disease, and transplantation. My goals are to identify novel biomarkers/immune signatures that clinicians can utilize to diagnosis, predict disease outcomes, and determine patients' response to treatment. 

Education and Training

  • Ph.D., University of Alabama Birmingham, 2010


Ingram, Jennifer T., John S. Yi, and Allan J. Zajac. “Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.” Plos Pathog 7, no. 9 (September 2011): e1002273.

Full Text

Yi, John S., Jennifer T. Ingram, and Allan J. Zajac. “IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.” J Immunol 185, no. 8 (October 15, 2010): 4835–45.

Full Text

Yi, John, Ming Du, and Allan Zajac. “IL-21 Dictates the Quality and Maintenance of CD8 T Cell Responses during Acute and Chronic Infections.” In Clinical Immunology, 135:S33–S33. Elsevier BV, 2010.

Full Text

Hsu, Hui-Chen, PingAr Yang, John Wang, Qi Wu, Riley Myers, Jian Chen, John Yi, et al. “Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.” Nat Immunol 9, no. 2 (February 2008): 166–75.

Full Text

Michalek, Ryan D., Kimberly J. Nelson, Beth C. Holbrook, John S. Yi, Daya Stridiron, Larry W. Daniel, Jacquelyn S. Fetrow, S Bruce King, Leslie B. Poole, and Jason M. Grayson. “The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.” J Immunol 179, no. 10 (November 15, 2007): 6456–67.

Full Text

Michalek, Ryan D., Kimberly J. Nelson, John S. Yi, Daya Stridiron, S Bruce King, Leslie B. Poole, and Jason M. Grayson. “The Requirement of Reversible Cysteine Sulfenic Acid Formation in T Cell Activation and Function.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.


Yi, John S., Beth C. Holbrook, Ryan D. Michalek, Nathan G. Laniewski, and Jason M. Grayson. “Electron transport complex I is required for CD8+ T cell function.” J Immunol 177, no. 2 (July 15, 2006): 852–62.

Full Text