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John S Yi, PhD

Assistant Professor of Surgery
Office: 915 S. Lasalle Street, 204 Sorf (Bldg. 41) Box 2926, Durham, NC 27710

I am an immunologist, with a focus to characterize the immune system in response to infectious and non-infectious diseases including cancer, HIV, autoimmune disease, and transplantation. My goals are to identify novel biomarkers/immune signatures that clinicians can utilize to diagnosis, predict disease outcomes, and determine patients' response to treatment. 

Education and Training

  • Ph.D., University of Alabama Birmingham, 2010

Publications

Yi, J. S., A. Guidon, S. Sparks, R. Osborne, V. C. Juel, J. M. Massey, D. B. Sanders, K. J. Weinhold, and J. T. Guptill. “Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis.” J Autoimmun 52 (August 2014): 130–38. https://doi.org/10.1016/j.jaut.2013.12.005.

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Yi, J. S., E. Choi, D. B. Sanders, K. J. Weinhold, and J. T. Guptill. “PROLONGED B CELL DEPLETION IN MUSK MYASTHENIA GRAVIS FOLLOWING RITUXIMAB TREATMENT.” In Muscle & Nerve, 48:691–691. WILEY-BLACKWELL, 2013.

Scholars@Duke

Yi, John, and Kent Weinhold. “The role of IL-21 in rescuing CD8 T Cell responses in chronically infected HIV patients.” In Journal of Immunology, Vol. 188. AMER ASSOC IMMUNOLOGISTS, 2012.

Scholars@Duke

Ingram, Jennifer T., John S. Yi, and Allan J. Zajac. “Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.” Plos Pathog 7, no. 9 (September 2011): e1002273. https://doi.org/10.1371/journal.ppat.1002273.

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Yi, John S., Jennifer T. Ingram, and Allan J. Zajac. “IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.” J Immunol 185, no. 8 (October 15, 2010): 4835–45. https://doi.org/10.4049/jimmunol.1001032.

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Yi, John, Ming Du, and Allan Zajac. “IL-21 Dictates the Quality and Maintenance of CD8 T Cell Responses during Acute and Chronic Infections.” In Clinical Immunology, 135:S33–S33. Elsevier BV, 2010. https://doi.org/10.1016/j.clim.2010.03.102.

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Hsu, Hui-Chen, PingAr Yang, John Wang, Qi Wu, Riley Myers, Jian Chen, John Yi, et al. “Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.” Nat Immunol 9, no. 2 (February 2008): 166–75. https://doi.org/10.1038/ni1552.

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