Skip to main content

John S Yi, PhD

Assistant Professor of Surgery
Office: 915 S. Lasalle Street, 204 Sorf (Bldg. 41) Box 2926, Durham, NC 27710

I am an immunologist, with a focus to characterize the immune system in response to infectious and non-infectious diseases including cancer, HIV, autoimmune disease, and transplantation. My goals are to identify novel biomarkers/immune signatures that clinicians can utilize to diagnosis, predict disease outcomes, and determine patients' response to treatment. 

Education and Training

  • Ph.D., University of Alabama Birmingham, 2010

Publications

Ingram, Jennifer T., John S. Yi, and Allan J. Zajac. “Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.” Plos Pathog 7, no. 9 (September 2011): e1002273. https://doi.org/10.1371/journal.ppat.1002273.

Full Text

Yi, John S., Jennifer T. Ingram, and Allan J. Zajac. “IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.” J Immunol 185, no. 8 (October 15, 2010): 4835–45. https://doi.org/10.4049/jimmunol.1001032.

Full Text

Yi, John, Ming Du, and Allan Zajac. “IL-21 Dictates the Quality and Maintenance of CD8 T Cell Responses during Acute and Chronic Infections.” In Clinical Immunology, 135:S33–S33. Elsevier BV, 2010. https://doi.org/10.1016/j.clim.2010.03.102.

Full Text

Hsu, Hui-Chen, PingAr Yang, John Wang, Qi Wu, Riley Myers, Jian Chen, John Yi, et al. “Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.” Nat Immunol 9, no. 2 (February 2008): 166–75. https://doi.org/10.1038/ni1552.

Full Text

Michalek, Ryan D., Kimberly J. Nelson, Beth C. Holbrook, John S. Yi, Daya Stridiron, Larry W. Daniel, Jacquelyn S. Fetrow, S Bruce King, Leslie B. Poole, and Jason M. Grayson. “The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.” J Immunol 179, no. 10 (November 15, 2007): 6456–67. https://doi.org/10.4049/jimmunol.179.10.6456.

Full Text

Michalek, Ryan D., Kimberly J. Nelson, John S. Yi, Daya Stridiron, S Bruce King, Leslie B. Poole, and Jason M. Grayson. “The Requirement of Reversible Cysteine Sulfenic Acid Formation in T Cell Activation and Function.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.

Scholars@Duke

Yi, John S., Beth C. Holbrook, Ryan D. Michalek, Nathan G. Laniewski, and Jason M. Grayson. “Electron transport complex I is required for CD8+ T cell function.” J Immunol 177, no. 2 (July 15, 2006): 852–62. https://doi.org/10.4049/jimmunol.177.2.852.

Full Text

Pages