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John S Yi, PhD

Assistant Professor of Surgery
Division: 
Surgical Sciences
Faculty Lab: 
Immune Mechanisms of Disease Pathogenesis Laboratory
Office: 915 S. Lasalle Street, 204 Sorf (Bldg. 41) Box 2926, Durham, NC 27710

I am an immunologist, with a focus to characterize the immune system in response to infectious and non-infectious diseases including cancer, HIV, autoimmune disease, and transplantation. My goals are to identify novel biomarkers/immune signatures that clinicians can utilize to diagnosis, predict disease outcomes, and determine patients' response to treatment. 

Education and Training

  • Ph.D., University of Alabama Birmingham, 2010

Selected Grants

Publications

Kwun, Jean, Jaeberm Park, John S. Yi, Alton B. Farris, Allan D. Kirk, and Stuart J. Knechtle. “IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.” Front Immunol 9 (2018): 2323. https://doi.org/10.3389/fimmu.2018.02323.

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Yi, John S., Neal Ready, Patrick Healy, Chelsae Dumbauld, Robyn Osborne, Mark Berry, Debra Shoemaker, et al. “Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab.” Clin Cancer Res 23, no. 24 (December 15, 2017): 7474–82. https://doi.org/10.1158/1078-0432.CCR-17-2005.

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Kwun, Jean, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, et al. “Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates.” Blood Adv 1, no. 24 (November 14, 2017): 2115–19. https://doi.org/10.1182/bloodadvances.2017010991.

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Gaillard, Stephanie, Chelsae Dumbauld, Alyssa Bilewski, Jessie A. Ehrisman, Angeles Alvarez Secord, Laura Jean Havrilesky, Andrew Berchuck, Kent Weinhold, Cliburn Chan, and John Yi. “Evaluating the repertoire of immune checkpoint markers expressed on peripheral and ascites CD8+ T cells in ovarian cancer.” In Journal of Clinical Oncology, 35:5571–5571. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.5571.

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Yi, John, Jeffrey Melson Clarke, Patrick Healy, Xiaofei F. Wang, Debra Shoemaker, Mark W. Onaitis, Chelsae Dumbauld, et al. “Immune profiling of circulating T cells and TILs following neoadjuvant ipilimumab and chemotherapy in non-small cell lung cancer (NSCLC).” In Journal of Clinical Oncology, 35:26–26. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.7_suppl.26.

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Yi, John S., Melissa A. Russo, Janice M. Massey, Vern Juel, Lisa D. Hobson-Webb, Karissa Gable, Shruti M. Raja, Kristina Balderson, Kent J. Weinhold, and Jeffrey T. Guptill. “B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.” Front Neurol 8 (2017): 34. https://doi.org/10.3389/fneur.2017.00034.

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Guptill, Jeffrey T., Vern C. Juel, Janice M. Massey, Amanda C. Anderson, Manisha Chopra, John S. Yi, Ehsanollah Esfandiari, et al. “Effect of therapeutic plasma exchange on immunoglobulins in myasthenia gravis.” Autoimmunity 49, no. 7 (November 2016): 472–79. https://doi.org/10.1080/08916934.2016.1214823.

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Gaillard, Stephanie, John Yi, Chelsae Dumbauld, Jessie Ehrisman, Andrew Berchuck, and Kent Weinhold. “Evaluating the Repertoire of Immune Checkpoint Markers Expressed Within Ovarian Cancers.” Journal of Womens Health 25, no. 9 (September 1, 2016): 962–962.

Scholars@Duke

Yi, John S., Melissa A. Russo, Kent J. Weinhold, and Jeffrey T. Guptill. “Adaptive immune response to therapy in hmgcr autoantibody myopathy.” Muscle Nerve 53, no. 2 (February 2016): 313–17. https://doi.org/10.1002/mus.24947.

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Snyder, Laurie D., Cliburn Chan, Darongsae Kwon, John S. Yi, Jessica A. Martissa, C Ashley Finlen Copeland, Robyn J. Osborne, Sara D. Sparks, Scott M. Palmer, and Kent J. Weinhold. “Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation.” Am J Respir Crit Care Med 193, no. 1 (January 1, 2016): 78–85. https://doi.org/10.1164/rccm.201504-0733OC.

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