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John S Yi, PhD

Assistant Professor of Surgery
Office: 915 S. Lasalle Street, 204 Sorf (Bldg. 41) Box 2926, Durham, NC 27710

I am an immunologist, with a focus to characterize the immune system in response to infectious and non-infectious diseases including cancer, HIV, autoimmune disease, and transplantation. My goals are to identify novel biomarkers/immune signatures that clinicians can utilize to diagnosis, predict disease outcomes, and determine patients' response to treatment. 

Education and Training

  • Ph.D., University of Alabama at Birmingham, 2010

Publications

Li, Y, Guptill, JT, Russo, MA, Massey, JM, Juel, VC, Hobson-Webb, LD, Howard, JF, Chopra, M, Liu, W, and Yi, JS. "Tacrolimus inhibits Th1 and Th17 responses in MuSK-antibody positive myasthenia gravis patients." Experimental Neurology 312 (November 22, 2018): 43-50.

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Yi, JS, Guptill, JT, Stathopoulos, P, Nowak, RJ, and O'Connor, KC. "B cells in the pathophysiology of myasthenia gravis." Muscle & nerve 57, no. 2 (February 2018): 172-184.

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Reap, EA, Suryadevara, CM, Batich, KA, Sanchez-Perez, L, Archer, GE, Schmittling, RJ, Norberg, PK, Herndon, JE, Healy, P, Congdon, KL, Gedeon, PC, Campbell, OC, Swartz, AM, Riccione, KA, Yi, JS, Hossain-Ibrahim, MK, Saraswathula, A, Nair, SK, Dunn-Pirio, AM, Broome, TM, Weinhold, KJ, Desjardins, A, Vlahovic, G, McLendon, RE, Friedman, AH, Friedman, HS, Bigner, DD, Fecci, PE, Mitchell, DA, and Sampson, JH. "Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma." Cancer Research 78, no. 1 (January 2018): 256-264.

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Kwun, J, Park, J, Yi, JS, Farris, AB, Kirk, AD, and Knechtle, SJ. "IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade." Frontiers in Immunology 9 (January 2018): 2323-null.

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Yi, JS, Ready, N, Healy, P, Dumbauld, C, Osborne, R, Berry, M, Shoemaker, D, Clarke, J, Crawford, J, Tong, B, Harpole, D, D'Amico, TA, McSherry, F, Dunphy, F, McCall, SJ, Christensen, JD, Wang, X, and Weinhold, KJ. "Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 24 (December 2017): 7474-7482.

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Kwun, J, Burghuber, C, Manook, M, Ezekian, B, Park, J, Yoon, J, Yi, JS, Iwakoshi, N, Gibby, A, Hong, JJ, Farris, AB, Kirk, AD, and Knechtle, SJ. "Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates." Blood advances 1, no. 24 (November 2017): 2115-2119.

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Yi, JS, Russo, MA, Massey, JM, Juel, V, Hobson-Webb, LD, Gable, K, Raja, SM, Balderson, K, Weinhold, KJ, and Guptill, JT. "B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity." Frontiers in Neurology 8 (January 2017): 34-.

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Guptill, JT, Juel, VC, Massey, JM, Anderson, AC, Chopra, M, Yi, JS, Esfandiari, E, Buchanan, T, Smith, B, Atherfold, P, Jones, E, and Howard, JF. "Effect of therapeutic plasma exchange on immunoglobulins in myasthenia gravis." Autoimmunity 49, no. 7 (November 2016): 472-479.

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Yi, JS, Russo, MA, Weinhold, KJ, and Guptill, JT. "Adaptive immune response to therapy in hmgcr autoantibody myopathy." Muscle & nerve 53, no. 2 (February 2016): 313-317.

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Snyder, LD, Chan, C, Kwon, D, Yi, JS, Martissa, JA, Copeland, CAF, Osborne, RJ, Sparks, SD, Palmer, SM, and Weinhold, KJ. "Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation." American Journal of Respiratory and Critical Care Medicine 193, no. 1 (January 2016): 78-85.

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