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John S Yi, PhD

Adjunct Assistant Professor in the Department of Surgery
Office: 915 S. Lasalle Street, 204 Sorf (Bldg. 41) Box 2926, Durham, NC 27710

I am an immunologist, with a focus to characterize the immune system in response to infectious and non-infectious diseases including cancer, HIV, autoimmune disease, and transplantation. My goals are to identify novel biomarkers/immune signatures that clinicians can utilize to diagnosis, predict disease outcomes, and determine patients' response to treatment. 

Education and Training

  • Ph.D., University of Alabama Birmingham, 2010

Publications

Li, Yingkai, John S. Yi, Melissa A. Russo, Marilyn Rosa-Bray, Kent J. Weinhold, and Jeffrey T. Guptill. “Normative dataset for plasma cytokines in healthy human adults.” Data Brief 35 (April 2021): 106857. https://doi.org/10.1016/j.dib.2021.106857.

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Guptill, Jeffrey T., Richard Barfield, Cliburn Chan, Melissa A. Russo, Doug Emmett, Shruti Raja, Janice M. Massey, et al. “Reduced plasmablast frequency is associated with seronegative myasthenia gravis.” Muscle Nerve 63, no. 4 (April 2021): 577–85. https://doi.org/10.1002/mus.27140.

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Salama, April K. S., Manisha Palta, Christel N. Rushing, M Angelica Selim, Kristen N. Linney, Brian G. Czito, David S. Yoo, et al. “Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.” Clin Cancer Res 27, no. 5 (March 1, 2021): 1287–95. https://doi.org/10.1158/1078-0432.CCR-20-2452.

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Furman, B. D., J. H. Zeitlin, M. W. Buchanan, J. L. Huebner, V. B. Kraus, J. S. Yi, S. B. Adams, and S. A. Olson. “Immune cell profiling in the joint following human and murine articular fracture.” Osteoarthritis Cartilage, February 25, 2021. https://doi.org/10.1016/j.joca.2021.02.565.

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Buchanan, Michael W., Bridgette D. Furman, Jacob H. Zeitlin, Janet L. Huebner, Virginia B. Kraus, John S. Yi, and Steven A. Olson. “Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.” J Orthop Res, October 26, 2020. https://doi.org/10.1002/jor.24899.

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Gaillard, S., G. Broadwater, W. S. Andrews, M. D. Starr, R. A. Previs, L. J. Havrilesky, B. A. Davidson, et al. “Pembrolizumab window study: Illuminating the immunologic landscape in gynecologic cancers.” In Gynecologic Oncology, 159:41–41. Elsevier BV, 2020. https://doi.org/10.1016/j.ygyno.2020.06.087.

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Li, Yingkai, Jeffrey T. Guptill, Melissa A. Russo, James F. Howard, Janice M. Massey, Vern C. Juel, Lisa D. Hobson-Webb, et al. “Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.” J Neuroimmunol 345 (August 15, 2020): 577279. https://doi.org/10.1016/j.jneuroim.2020.577279.

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Yi, John S., Melissa A. Russo, Shruti Raja, Janice M. Massey, Vern C. Juel, Jay Shin, Lisa D. Hobson-Webb, Karissa Gable, and Jeffrey T. Guptill. “Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.” Exp Neurol 325 (March 2020): 113146. https://doi.org/10.1016/j.expneurol.2019.113146.

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Ezekian, Brian, Paul M. Schroder, Michael S. Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, et al. “Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients.” J Am Soc Nephrol 30, no. 12 (December 2019): 2399–2411. https://doi.org/10.1681/ASN.2019030304.

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Kwun, Jean, Marie Matignon, Miriam Manook, Soulef Guendouz, Vincent Audard, David Kheav, Elsa Poullot, et al. “Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use.” J Am Soc Nephrol 30, no. 7 (July 2019): 1206–19. https://doi.org/10.1681/ASN.2018121254.

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