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Jean Kwun, PhD

Assistant Professor in Surgery
Office: 362 Jones Building, 207 Research Dr, Durham, NC 27710

Research interests include humoral tolerance to organ transplants in animal model and humans, developing a clinically relevant animal model to study the mechanisms of antibody-mediated rejection (AMR), and establishing a conceptual basis that will translate into therapeutic intervention of AMR.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 2007

Publications

Kwun, J., E. Page, A. Gibby, J. Hong, A. Farris, F. Villinger, and S. Knechtle. “The Effect of Neutralizing BAFF With Atacicept in a T Cell Depletion-Induced Nonhuman Primate AMR Model.” In American Journal of Transplantation, 14:380–81. WILEY-BLACKWELL, 2014.

Scholars@Duke

Kwun, J., B. Oh, M. MaConmara, H. Song, and S. Knechtle. “The Role of Splenic CD4(+)CD25(+) T reg Cells On Alloreactive B Cell Formation and DSA Production in a Murine CAMR Model.” In American Journal of Transplantation, 14:385–385. WILEY-BLACKWELL, 2014.

Scholars@Duke

Kim, E. J., J. Kwun, A. C. Gibby, J. J. Hong, A. B. Farris, N. N. Iwakoshi, F. Villinger, A. D. Kirk, and S. J. Knechtle. “Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.” Am J Transplant 14, no. 1 (January 2014): 59–69. https://doi.org/10.1111/ajt.12526.

Full Text

Oh, B., J. Kwun, R. Ruhil, A. Gibby, A. Kirk, S. Knechtle, and N. Iwakoshi. “CTLA-4 Ig Prevents Chronic Antibody-Mediated Rejection.” In American Journal of Transplantation, 13:463–463. WILEY-BLACKWELL, 2013.

Scholars@Duke

Kwun, J., E. Page, A. Gibby, J. Hong, A. Farris, A. Adams, N. Iwakoshi, C. Larsen, A. Kirk, and S. Knechtle. “Follicular Helper T Cell Modulation by Costimulation Blockade Prevents Antibody-Mediated Rejection in Nonhuman Primate Renal Transplantation.” In American Journal of Transplantation, 13:177–177. WILEY-BLACKWELL, 2013.

Scholars@Duke

Page, E., J. Kwun, A. Gibby, S. Knechtle, and N. Iwakoshi. “Immunophenotyping and Targeting of Plasma Cells in Sensitized Nonhuman Primates.” In American Journal of Transplantation, 13:461–461. WILEY-BLACKWELL, 2013.

Scholars@Duke

Oh, B., J. Kwun, R. Ruhil, A. Gibby, E. Page, A. Farris, A. Kirk, N. Iwakoshi, and S. Knechtle. “Rapamycin Enhances Early Alloantibody Production by Hampering the Homeostatic Proliferation of Regulatory T Cells.” In American Journal of Transplantation, 13:383–84. WILEY-BLACKWELL, 2013.

Scholars@Duke

Page, E., J. Kwun, A. Gibby, B. Oh, N. Iwakoshi, and S. Knechtle. “The Development of a Nonhuman Primate Model of Sensitization after Transplantation.” In American Journal of Transplantation, 13:462–462. WILEY-BLACKWELL, 2013.

Scholars@Duke

Kwun, J., E. Page, A. Gibby, N. Iwakoshi, and S. Knechtle. “The Effect of Belatacept on Follicular Helper T Cell and Humoral Response in Sensitized Rhesus Macaques.” In American Journal of Transplantation, 13:465–465. WILEY-BLACKWELL, 2013.

Scholars@Duke

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