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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Nelson, Cody S., Justin Pollara, Erika L. Kunz, Thomas L. Jeffries, Ryan Duffy, Charles Beck, Lisa Stamper, et al. “Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk..” J Virol 90, no. 10 (May 15, 2016): 4951–65. https://doi.org/10.1128/JVI.00335-16.

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Clutton, Genevieve Tyndale, Yinyan Xu, Maria Abad Fernandez, Amanda Crooks, Blair Turner, Nicole Maponga, Anna Cope, et al. “Effects of different treatment regimens on T cell function in acute HIV infection.” In Journal of Immunology, Vol. 196. AMER ASSOC IMMUNOLOGISTS, 2016.

Scholars@Duke

Asbach, Benedikt, Alexander Kliche, Josef Köstler, Beatriz Perdiguero, Mariano Esteban, Bertram L. Jacobs, David C. Montefiori, et al. “Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens..” J Virol 90, no. 8 (April 2016): 4133–49. https://doi.org/10.1128/JVI.03135-15.

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Jeffries, T. L., C. R. Sacha, J. Pollara, J. Himes, F. H. Jaeger, S. M. Dennison, E. McGuire, et al. “The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells..” Mucosal Immunol 9, no. 2 (March 2016): 414–27. https://doi.org/10.1038/mi.2015.70.

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Ding, Shilei, Maxime Veillette, Mathieu Coutu, Jérémie Prévost, Louise Scharf, Pamela J. Bjorkman, Guido Ferrari, et al. “A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies..” J Virol 90, no. 4 (February 15, 2016): 2127–34. https://doi.org/10.1128/JVI.02779-15.

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Joachim, Agricola, Asli Bauer, Sarah Joseph, Christof Geldmacher, Patricia J. Munseri, Said Aboud, Marco Missanga, et al. “Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Trial..” Plos One 11, no. 5 (2016). https://doi.org/10.1371/journal.pone.0155702.

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Cosgrove, Catherine A., Charles J. Lacey, Alethea V. Cope, Angela Bartolf, Georgina Morris, Celine Yan, Susan Baden, et al. “Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study..” Plos One 11, no. 5 (2016). https://doi.org/10.1371/journal.pone.0152038.

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Zurawski, Gerard, Sandra Zurawski, Anne-Laure Flamar, Laura Richert, Ralf Wagner, Georgia D. Tomaras, David C. Montefiori, et al. “Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques..” Plos One 11, no. 4 (2016). https://doi.org/10.1371/journal.pone.0153484.

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Lai, Weihong, Li Huang, Lei Zhu, Guido Ferrari, Cliburn Chan, Wei Li, Kuo-Hsiung Lee, and Chin-Ho Chen. “Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β..” J Med Chem 58, no. 21 (November 12, 2015): 8638–46. https://doi.org/10.1021/acs.jmedchem.5b01233.

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Sung, Julia A. M., Joy Pickeral, Liqin Liu, Sherry A. Stanfield-Oakley, Chia-Ying Kao Lam, Carolina Garrido, Justin Pollara, et al. “Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells..” J Clin Invest 125, no. 11 (November 2, 2015): 4077–90. https://doi.org/10.1172/JCI82314.

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