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Debara Lyn Tucci, MD

Adjunct Professor in the Department of Surgery
Office: 1559 Hosp South, Blue Zone, Durham, NC 27710
Campus Mail: DUMC Box 3805 Med Ctr, Durham, NC 27710

The focus of current research efforts is in defining the effects of conductive hearing impairment on the development and function of the central auditory system. The ultimate goal of this research is to understand the impact of hearing loss, such as that associated with otitis media, on the development of auditory function in children. Experiments are currently being performed in which central auditory system activity is studied using the 2-deoxyglucose method following unilateral neonatal conductive hearing loss. Future experiments will examine changes in cell structure and interneuronal connections following acute and chronic conductive hearing loss in both neonatal and adult animals.

A second research program is focused on issues related to the cochlear implant. The cochlear implant is a device which allows for electrical stimulation of the auditory nerve in profoundly deaf patients. It has previously been demonstrated in animal studies as well as in human tissue histopathology that degeneration of central auditory pathways occurs following severe damage to the inner ear. It has been suggested that the introduction of electrical stimulation via a cochlear implant may prevent or reverse some of these degenerative changes. Experiments conducted previously examined this issue in the neonatally and adult deafened rat. Tissue analysis is currently undergoing completion.

Education and Training

  • M.D., University of Virginia, 1985
Weight: 
-20

Publications

Tucci, D. L., R. A. Ruth, and P. R. Lambert. “Use of the bone conduction ABR Wave I response in determination of cochlear reserve..” Am J Otol 11, no. 2 (March 1990): 119–24.

Scholars@Duke

Tucci, D. L., D. E. Born, and E. W. Rubel. “Changes in spontaneous activity and CNS morphology associated with conductive and sensorineural hearing loss in chickens..” Ann Otol Rhinol Laryngol 96, no. 3 Pt 1 (May 1987): 343–50. https://doi.org/10.1177/000348948709600321.

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Tucci, D. L., and E. W. Rubel. “Afferent influences on brain stem auditory nuclei of the chicken: effects of conductive and sensorineural hearing loss on n. magnocellularis..” J Comp Neurol 238, no. 4 (August 22, 1985): 371–81. https://doi.org/10.1002/cne.902380402.

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Delanoy, R. L., D. L. Tucci, and P. E. Gold. “Amphetamine effects on long term potentiation in dentate granule cells..” Pharmacol Biochem Behav 18, no. 1 (January 1983): 137–39. https://doi.org/10.1016/0091-3057(83)90263-0.

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