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Debara Lyn Tucci, MD

Adjunct Professor in the Department of Surgery
Office: 1559 Hosp South, Blue Zone, Durham, NC 27710
Campus Mail: DUMC Box 3805 Med Ctr, Durham, NC 27710

The focus of current research efforts is in defining the effects of conductive hearing impairment on the development and function of the central auditory system. The ultimate goal of this research is to understand the impact of hearing loss, such as that associated with otitis media, on the development of auditory function in children. Experiments are currently being performed in which central auditory system activity is studied using the 2-deoxyglucose method following unilateral neonatal conductive hearing loss. Future experiments will examine changes in cell structure and interneuronal connections following acute and chronic conductive hearing loss in both neonatal and adult animals.

A second research program is focused on issues related to the cochlear implant. The cochlear implant is a device which allows for electrical stimulation of the auditory nerve in profoundly deaf patients. It has previously been demonstrated in animal studies as well as in human tissue histopathology that degeneration of central auditory pathways occurs following severe damage to the inner ear. It has been suggested that the introduction of electrical stimulation via a cochlear implant may prevent or reverse some of these degenerative changes. Experiments conducted previously examined this issue in the neonatally and adult deafened rat. Tissue analysis is currently undergoing completion.

Education and Training

  • M.D., University of Virginia, 1985

Publications

Witsell, David L., Kristine A. Schulz, Kathy Moore, Debara L. Tucci, and Debara L. CHEER Investigators. “Implementation and testing of research infrastructure for practice-based research in hearing and communication disorders..” Otolaryngol Head Neck Surg 145, no. 4 (October 2011): 565–71. https://doi.org/10.1177/0194599811406369.

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Witsell, David L., Steven D. Rauch, Debara L. Tucci, Steven A. Telian, Peter S. Roland, Anh T. Nguyen-Huynh, and Kristine Schulz. “The Otology Data Collection project: report from the CHEER network..” Otolaryngol Head Neck Surg 145, no. 4 (October 2011): 572–80. https://doi.org/10.1177/0194599811416063.

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Wilson, Blake S., Michael F. Dorman, Marty G. Woldorff, and Debara L. Tucci. “Cochlear implants matching the prosthesis to the brain and facilitating desired plastic changes in brain function..” Prog Brain Res 194 (2011): 117–29. https://doi.org/10.1016/B978-0-444-53815-4.00012-1.

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Schellenberg, Kerri, Richard Bedlack, and Debara Tucci. “Roaring in the ears: patulous Eustachian tube in bulbar amyotrophic lateral sclerosis..” Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 11, no. 4 (August 2010): 395–96. https://doi.org/10.3109/17482960903501931.

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Aliabadi, Hamidreza, James J. Vredenburgh, Richard G. Everson, Annick Desjardins, Henry S. Friedman, Roger E. McLendon, Debara L. Tucci, and John H. Sampson. “Bevacizumab fails to treat temporal paraganglioma: discussion and case illustration..” Journal of Neuro Oncology 98, no. 3 (July 2010): 427–30. https://doi.org/10.1007/s11060-009-0091-2.

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Tucci, Debara L., Kristine Schulz, and David L. Witsell. “Building a national research network for clinical investigations in otology and neurotology..” Otol Neurotol 31, no. 2 (February 2010): 190–95. https://doi.org/10.1097/MAO.0b013e3181c9940c.

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Tucci, Debara, Michael H. Merson, and Blake S. Wilson. “A summary of the literature on global hearing impairment: current status and priorities for action..” Otol Neurotol 31, no. 1 (January 2010): 31–41. https://doi.org/10.1097/mao.0b013e3181c0eaec.

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Tebbit, C. L., T. Pilkington, S. Ciecko, D. Kaylie, and D. Tucci. “Management of temporal bone osteoradionecrosis: Surgical and adjunctive therapies.” In Laryngoscope, Vol. 119, 2009. https://doi.org/10.1002/lary.21559.

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