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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2004

Publications

Huang, Lin-Ya, Ami Patel, Robert Ng, Edward B. Miller, Sujata Halder, Robert McKenna, Aravind Asokan, and Mavis Agbandje-McKenna. “727. Characterizing the Adeno-Associated Virus 1 Sialic Receptor Binding Site and Its Overlap with Antigenic Epitopes.” In Molecular Therapy, 24:S287–S287. Elsevier BV, 2016. https://doi.org/10.1016/s1525-0016(16)33535-3.

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Schreiber, Claire A., Yoshihiro Izumiya, Aravind Asokan, and Yasuhiro Ikeda. “8. Further Characterization of U2 snRNP Mediated Restriction of AAV Vector Transduction.” In Molecular Therapy, 24:S4–5. Elsevier BV, 2016. https://doi.org/10.1016/s1525-0016(16)32817-9.

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Murlidharan, Giridhar, and Aravind Asokan. “Aquaporins and CSF Flux Are Critical Determinants of AAV Mediated CNS Gene Transfer.” In Molecular Therapy, 24:S24–S24. NATURE PUBLISHING GROUP, 2016.

Scholars@Duke

Vance, Melisa, Telmo Llanga, Will Bennett, Kenton Woodard, Giridhar Murlidharan, Neil Chungfat, Aravind Asokan, et al. “AAV Gene Therapy for MPS1-associated Corneal Blindness..” Sci Rep 6 (February 22, 2016). https://doi.org/10.1038/srep22131.

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Li, Chengwen, Shuqing Wu, Blake Albright, Matthew Hirsch, Wuping Li, Yu-Shan Tseng, Mavis Agbandje-McKenna, Scott McPhee, Aravind Asokan, and R Jude Samulski. “Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer..” Mol Ther 24, no. 1 (February 2016): 53–65. https://doi.org/10.1038/mt.2015.134.

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Nelson, Christopher E., Chady H. Hakim, David G. Ousterout, Pratiksha I. Thakore, Eirik A. Moreb, Ruth M. Castellanos Rivera, Sarina Madhavan, et al. “In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy..” Science 351, no. 6271 (January 22, 2016): 403–7. https://doi.org/10.1126/science.aad5143.

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Murlidharan, G., R. J. Samulski, and A. Asokan. “Gene therapy of CNS disorders using recombinant AAV vectors.” In Translational Neuroscience: Fundamental Approaches for Neurological Disorders, 9–24, 2016. https://doi.org/10.1007/978-1-4899-7654-3_2.

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Borchardt, Erin K., Leonidas A. Vandoros, Michael Huang, Patrick E. Lackey, William F. Marzluff, and Aravind Asokan. “Controlling mRNA stability and translation with the CRISPR endoribonuclease Csy4..” Rna 21, no. 11 (November 2015): 1921–30. https://doi.org/10.1261/rna.051227.115.

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Schreiber, C. A., T. Sakuma, Y. Izumiya, R. K. Bressin, U. Basu, K. Koide, A. Asokan, and Y. Ikeda. “Enhanced AAV vector transduction through genetic and pharmacological inhibition of U2 snRNP components.” In Human Gene Therapy, 26:A3–4. MARY ANN LIEBERT, INC, 2015.

Scholars@Duke

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