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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin at Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants


Ross, J. R., A. D. Kirk, S. E. Ibrahim, D. N. Howell, W. M. Baldwin, and F. P. Sanfilippo. “Characterization of human anti-porcine "natural antibodies" recovered from ex vivo perfused hearts--predominance of IgM and IgG2.” Transplantation 55, no. 5 (May 1993): 1144–50.

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Kirk, A. D., R. A. Li, M. S. Kinch, K. A. Abernethy, C. Doyle, and R. R. Bollinger. “The human antiporcine cellular repertoire. In vitro studies of acquired and innate cellular responsiveness.” Transplantation 55, no. 4 (April 1993): 924–31.


Li, R. A., A. D. Kirk, K. A. Abernathy, and R. R. Bollinger. “Human antiporcine mixed lymphocyte reaction.” Transplant Proc 25, no. 1 Pt 1 (February 1993): 442–43.


Kirk, A. D., S. Ibrahim, D. V. Dawson, F. Sanfilippo, and O. J. Finn. “Characterization of T cells expressing the gamma/delta antigen receptor in human renal allografts.” Human Immunology 36, no. 1 (January 1993): 11–19.

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Hall, B. L., S. L. Hand, M. D. Alter, A. D. Kirk, and O. J. Finn. “Variables affecting the T cell receptor V beta repertoire heterogeneity of T cells infiltrating human renal allografts.” Transplant Immunology 1, no. 3 (January 1993): 217–27.

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Kirk, A. D., B. L. Hall, O. J. Finn, and R. R. Bollinger. “In vitro analysis of the human antiporcine T-cell repertoire.” Transplant Proc 24, no. 2 (April 1992): 602–3.


Kirk, A. D., M. A. Ibrahim, R. R. Bollinger, D. V. Dawson, and O. J. Finn. “Renal allograft-infiltrating lymphocytes. A prospective analysis of in vitro growth characteristics and clinical relevance.” Transplantation 53, no. 2 (February 1992): 329–38.

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Kirk, A. D., and O. J. Finn. “T cells expressing the antigen receptor mediate non-MHC directed human renal allograft cytotoxicity.” Surgical Forum 52 (1991): 384–86.