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Allan Douglas Kirk, MD, PhD

David C. Sabiston, Jr. Distinguished Professor of Surgery
Chair, Department of Surgery
Professor of Surgery
Professor in Pediatrics
Professor in the Department of Immunology
Campus Mail: DUMC 3704, Durham, NC 27710

I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.

Costimulation Blockade in Organ Transplantion

Allan D. Kirk, MD, PhD, Department of Surgery Chairman
David C. Sabiston, Jr. Professor of Surgery

Education and Training

  • Fellow, Multi Organ Transplantation, University of Wisconsin - Madison, 1995 - 1997
  • Chief Resident, Surgery, Duke University, 1994 - 1995
  • Senior Resident, Surgery, Duke University, 1992 - 1994
  • Research Fellow, Surgery, Duke University, 1989 - 1992
  • Intern & Junior Resident, Surgery, Duke University, 1987 - 1989
  • Ph.D., Duke University, 1992
  • M.D., Duke University School of Medicine, 1987
  • B.S., Old Dominion University, 1983

Selected Grants

Publications

Rayhill, S. C., M. Heimes, A. D. Kirk, and H. W. Sollinger. “Simultaneous pancreas - kidney transplantation: Recent experience at the University of Wisconsin.” Experimental and Clinical Endocrinology and Diabetes 104, no. 5 (1996): 353–59.

Scholars@Duke

Kirk, A. D., R. R. Bollinger, and O. J. Finn. “Rapid, comprehensive analysis of human cytokine mRNA and its application to the study of acute renal allograft rejection.” Hum Immunol 43, no. 2 (June 1995): 113–28. https://doi.org/10.1016/0198-8859(94)00158-m.

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Rayhill, S. C., A. D. Kirk, J. S. Odorico, D. M. Heisey, C. B. Cangro, J. D. Pirsch, A. M. D’Alessandro, S. J. Knechtle, and H. W. Sollinger. “Simultaneous pancreas-kidney transplantation at the University of Wisconsin.” Clin Transpl, 1995, 261–69.

Scholars@Duke

Chari, R. S., B. H. Collins, J. C. Magee, J. M. DiMaio, A. D. Kirk, R. C. Harland, R. L. McCann, J. L. Platt, and W. C. Meyers. “Brief report: treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation.” N Engl J Med 331, no. 4 (July 28, 1994): 234–37. https://doi.org/10.1056/NEJM199407283310404.

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Pruitt, S. K., A. D. Kirk, R. R. Bollinger, H. C. Marsh, B. H. Collins, J. L. Levin, J. R. Mault, J. S. Heinle, S. Ibrahim, and A. R. Rudolph. “The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts.” Transplantation 57, no. 3 (February 1994): 363–70. https://doi.org/10.1097/00007890-199402150-00009.

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Ross, J. R., A. D. Kirk, S. E. Ibrahim, D. N. Howell, W. M. Baldwin, and F. P. Sanfilippo. “Characterization of human anti-porcine "natural antibodies" recovered from ex vivo perfused hearts--predominance of IgM and IgG2.” Transplantation 55, no. 5 (May 1993): 1144–50. https://doi.org/10.1097/00007890-199305000-00040.

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Kirk, A. D., R. A. Li, M. S. Kinch, K. A. Abernethy, C. Doyle, and R. R. Bollinger. “The human antiporcine cellular repertoire. In vitro studies of acquired and innate cellular responsiveness.” Transplantation 55, no. 4 (April 1993): 924–31.

Scholars@Duke

Li, R. A., A. D. Kirk, K. A. Abernathy, and R. R. Bollinger. “Human antiporcine mixed lymphocyte reaction.” Transplant Proc 25, no. 1 Pt 1 (February 1993): 442–43.

Scholars@Duke

Kirk, A. D., S. Ibrahim, D. V. Dawson, F. Sanfilippo, and O. J. Finn. “Characterization of T cells expressing the gamma/delta antigen receptor in human renal allografts.” Hum Immunol 36, no. 1 (January 1993): 11–19. https://doi.org/10.1016/0198-8859(93)90003-j.

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