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Alexander Tan Limkakeng Jr., MD, MHS

Director, Acute Care Research
Associate Professor of Surgery
Office: 2301 Erwin Road, Box 3096, Durham, NC 27710

My personal research interest is finding new ways to diagnose acute coronary syndrome. In particular, I am interested in novel biomarkers and precision medicine approaches to this problem. As Vice Chief of Research for the Duke Division of Emergency Medicine, I also work with researchers from many fields spanning global health, innovation, clinical trials, basic discovery and translational research. The common element is time-sensitive health conditions. I help to oversee a team of research professionals in multicenter emergency department studies funded by the National Institutes of Health, foundations, and industry partners.

Education and Training

  • M.H.S., Duke University, 2012
  • M.D., University of Pennsylvania, 2001

Publications

Kennedy, K., B. J. Theiling, A. T. Limkakeng, P. Manandhar, A. Erkanlu, and S. Pitts. “217 A Method for Stratifying Emergency Department Visits by Severity and Complexity: National Hospital Ambulatory Medical Care Survey Items.” In Annals of Emergency Medicine, 74:S85–86. Elsevier BV, 2019. https://doi.org/10.1016/j.annemergmed.2019.08.385.

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Limkakeng, A. T., L. -. L. Rowlette, O. Ilkayeva, J. Modliszewski, D. Corcoran, J. C. Leahy, S. M. Griffin, and D. Voora. “99EMF Pilot of Integrated Metabolomic and MicroRNA Analysis to Identify Myocardial Ischemia on Emergency Department Cardiac Stress Tests.” In Annals of Emergency Medicine, 74:S40–S40. Elsevier BV, 2019. https://doi.org/10.1016/j.annemergmed.2019.08.103.

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Eppensteiner, John, Jean Kwun, Uwe Scheuermann, Andrew Barbas, Alexander T. Limkakeng, Maggie Kuchibhatla, Eric A. Elster, Allan D. Kirk, and Jaewoo Lee. “Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness..” Jci Insight 4, no. 16 (August 22, 2019). https://doi.org/10.1172/jci.insight.127925.

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Fitzgerald, Robert L., Judd E. Hollander, W Frank Peacock, Alexander T. Limkakeng, Nancy Breitenbeck, Kareen Blechschmidt, Michael Laimighofer, and Christopher deFilippi. “Analytical performance evaluation of the Elecsys® Troponin T Gen 5 STAT assay..” Clin Chim Acta 495 (August 2019): 522–28. https://doi.org/10.1016/j.cca.2019.05.026.

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Beri, Neil, Lori B. Daniels, Allan Jaffe, Christian Mueller, Inder Anand, W Frank Peacock, Judd E. Hollander, et al. “Copeptin to rule out myocardial infarction in Blacks versus Caucasians..” Eur Heart J Acute Cardiovasc Care 8, no. 5 (August 2019): 395–403. https://doi.org/10.1177/2048872618772500.

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Sandoval, Yader, Richard Nowak, Christopher R. deFilippi, Robert H. Christenson, W Frank Peacock, James McCord, Alexander T. Limkakeng, Anne Sexter, and Fred S. Apple. “Myocardial Infarction Risk Stratification With a Single Measurement of High-Sensitivity Troponin I..” J Am Coll Cardiol 74, no. 3 (July 23, 2019): 271–82. https://doi.org/10.1016/j.jacc.2019.05.058.

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Christenson, R. H., W. F. Peacock, F. S. Apple, A. T. Limkakeng, R. M. Nowak, J. McCord, and C. R. deFilippi. “Trial design for assessing analytical and clinical performance of high-sensitivity cardiac troponin I assays in the United States: The HIGH-US study..” Contemp Clin Trials Commun 14 (June 2019). https://doi.org/10.1016/j.conctc.2019.100337.

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Limkakeng, Alexander T., Ricardo Henao, Deepak Voora, Thomas O’Connell, Michelle Griffin, Ephraim L. Tsalik, Svati Shah, Christopher W. Woods, and Geoffrey S. Ginsburg. “Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing..” Plos One 14, no. 2 (2019). https://doi.org/10.1371/journal.pone.0211762.

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