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Alexander Tan Limkakeng Jr., MD, MHS

Director, Acute Care Research
Professor of Surgery
Office: 2301 Erwin Road, Box 3096, Durham, NC 27710
Campus Mail: DUMC 2301 Erwin Road Box 3096, Durham, NC 27710

My personal research interest is finding new ways to diagnose acute coronary syndrome. In particular, I am interested in novel biomarkers and precision medicine approaches to this problem. I also have an interest in sepsis and empirical bioethics. As Vice Chief of Research for the Duke Division of Emergency Medicine, I also work with researchers from many fields spanning global health, innovation, clinical trials, basic discovery, and translational research. The common element is time-sensitive health conditions. I help to oversee a team of research professionals in multicenter emergency department studies funded by the National Institutes of Health, foundations, and industry partners.

Education and Training

  • M.H.S., Duke University, 2012
  • M.D., University of Pennsylvania, 2001

Selected Grants

Publications

Oyediran, Isaac O., Sainikitha Prattipati, Francis M. Sakita, Godfrey L. Kweka, Tumsifu G. Tarimo, Timothy Peterson, Zak Loring, Alexander T. Limkakeng, Gerald S. Bloomfield, and Julian T. Hertz. “The prevalence, management, and thirty-day outcomes of symptomatic atrial fibrillation in a Tanzanian emergency department.” Afr J Emerg Med 11, no. 4 (December 2021): 404–9. https://doi.org/10.1016/j.afjem.2021.07.002.

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Goli, Sumana, Francis M. Sakita, Godfrey L. Kweka, Tumsifu G. Tarimo, Gloria Temu, Nathan M. Thielman, Janet P. Bettger, Gerald S. Bloomfield, Alexander T. Limkakeng, and Julian T. Hertz. “Thirty-day outcomes and predictors of mortality following acute myocardial infarction in northern Tanzania: A prospective observational cohort study.” Int J Cardiol 342 (November 1, 2021): 23–28. https://doi.org/10.1016/j.ijcard.2021.08.002.

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Meltzer, Andrew C., Alexander T. Limkakeng, Nina T. Gentile, Jincong Q. Freeman, Nicole C. Hall, Nataly Montano Vargas, David E. Fleischer, et al. “Risk stratification with video capsule endoscopy leads to fewer hospital admissions in emergency department patients with low-risk to moderate-risk upper gastrointestinal bleed: A multicenter clinical trial.” J Am Coll Emerg Physicians Open 2, no. 5 (October 2021): e12579. https://doi.org/10.1002/emp2.12579.

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Limkakeng, Alexander T., Pratik Manandhar, Alaatin Erkanli, Stephanie A. Eucker, Adam Root, and Deepak Voora. “United States Emergency Department Use of Medications with Pharmacogenetic Recommendations.” West J Emerg Med 22, no. 6 (September 23, 2021): 1347–54. https://doi.org/10.5811/westjem.2021.5.51248.

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Gaspari, Romolo, Anthony Weekes, Srikar Adhikari, Vicki E. Noble, Jason T. Nomura, Daniel Theodoro, Michael Y. Woo, et al. “Comparison of outcomes between pulseless electrical activity by electrocardiography and pulseless myocardial activity by echocardiography in out-of-hospital cardiac arrest; secondary analysis from a large, prospective study.” Resuscitation, September 18, 2021. https://doi.org/10.1016/j.resuscitation.2021.09.010.

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Breslin, Adam W., Alexander T. Limkakeng, Elizabeth Silvius, Catherine A. Staton, Chandra Almond, Mary-Beth Joshi, Bartley Adams, et al. “Immune response profiling in patients with traumatic injuries associated with alcohol ingestion.” Clin Transl Sci 14, no. 5 (September 2021): 1791–98. https://doi.org/10.1111/cts.13022.

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Lee, Sangil, Samuel H. Lam, Thiago Augusto Hernandes Rocha, Ross J. Fleischman, Catherine A. Staton, Richard Taylor, and Alexander T. Limkakeng. “Machine Learning and Precision Medicine in Emergency Medicine: The Basics.” Cureus 13, no. 9 (September 2021): e17636. https://doi.org/10.7759/cureus.17636.

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Limkakeng, Alexander T., Julian Hertz, Reginald Lerebours, Maragatha Kuchibhatla, James McCord, Adam J. Singer, Fred S. Apple, William F. Peacock, Robert H. Christenson, and Richard M. Nowak. “Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction.” The American Journal of Emergency Medicine, August 28, 2021. https://doi.org/10.1016/j.ajem.2021.08.066.

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Hertz, Julian T., Deng B. Madut, Matthew P. Rubach, Gwamaka William, John A. Crump, Sophie W. Galson, Venance P. Maro, et al. “Incidence of Acute Myocardial Infarction in Northern Tanzania: A Modeling Approach Within a Prospective Observational Study.” J Am Heart Assoc 10, no. 15 (August 3, 2021): e021004. https://doi.org/10.1161/JAHA.121.021004.

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Limkakeng, Alexander T., Julian Hertz, Reginald Lerebours, Maragatha Kuchibhatla, James McCord, Adam J. Singer, Fred S. Apple, William F. Peacock, Robert H. Christenson, and Richard M. Nowak. “Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction.” Am J Emerg Med 46 (August 2021): 170–75. https://doi.org/10.1016/j.ajem.2020.06.072.

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