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Alexander Tan Limkakeng Jr., MD, MHS

Director, Acute Care Research
Professor of Surgery
Office: 2301 Erwin Road, Box 3096, Durham, NC 27710
Campus Mail: DUMC 2301 Erwin Road Box 3096, Durham, NC 27710

My personal research interest is finding new ways to diagnose acute coronary syndrome. In particular, I am interested in novel biomarkers and precision medicine approaches to this problem. I also have an interest in sepsis and empirical bioethics. As Vice Chief of Research for the Duke Division of Emergency Medicine, I also work with researchers from many fields spanning global health, innovation, clinical trials, basic discovery, and translational research. The common element is time-sensitive health conditions. I help to oversee a team of research professionals in multicenter emergency department studies funded by the National Institutes of Health, foundations, and industry partners.

Education and Training

  • M.H.S., Duke University, 2012
  • M.D., University of Pennsylvania, 2001

Selected Grants

Publications

Limkakeng, Alexander T., Laura-Leigh Rowlette, Ace Hatch, Andrew B. Nixon, Olga Ilkayeva, David Corcoran, Jennifer Modliszewski, Shannon Michelle Griffin, Geoffrey S. Ginsburg, and Deepak Voora. “A precision medicine approach to stress testing using metabolomics and microribonucleic acids.” Per Med, April 25, 2022. https://doi.org/10.2217/pme-2021-0021.

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Navas, Angelo, Billy Guzman, Almujtaba Hassan, Joseph B. Borawski, Dean Harrison, Pratik Manandhar, Alaatin Erkanli, and Alexander T. Limkakeng. “Untapped Potential for Emergency Department Observation Unit Use: A National Hospital Ambulatory Medical Care Survey (NHAMCS) Study.” West J Emerg Med 23, no. 2 (January 18, 2022): 134–40. https://doi.org/10.5811/westjem.2021.8.52231.

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Limkakeng, Alexander T., Jinny J. Ye, Catherine Staton, Yih Yng Ng, Benjamin S. H. Leong, Nur Shahidah, Muhammad Yazid, et al. “Impact of dispatcher-assisted cardiopulmonary resuscitation on performance of termination of resuscitation criteria.” Resuscitation 170 (January 2022): 160–66. https://doi.org/10.1016/j.resuscitation.2021.11.034.

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Gaspari, Romolo, Anthony Weekes, Srikar Adhikari, Vicki E. Noble, Jason T. Nomura, Daniel Theodoro, Michael Y. Woo, et al. “Comparison of outcomes between pulseless electrical activity by electrocardiography and pulseless myocardial activity by echocardiography in out-of-hospital cardiac arrest; secondary analysis from a large, prospective study.” Resuscitation 169 (December 2021): 167–72. https://doi.org/10.1016/j.resuscitation.2021.09.010.

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Oyediran, Isaac O., Sainikitha Prattipati, Francis M. Sakita, Godfrey L. Kweka, Tumsifu G. Tarimo, Timothy Peterson, Zak Loring, Alexander T. Limkakeng, Gerald S. Bloomfield, and Julian T. Hertz. “The prevalence, management, and thirty-day outcomes of symptomatic atrial fibrillation in a Tanzanian emergency department.” Afr J Emerg Med 11, no. 4 (December 2021): 404–9. https://doi.org/10.1016/j.afjem.2021.07.002.

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Goli, Sumana, Francis M. Sakita, Godfrey L. Kweka, Tumsifu G. Tarimo, Gloria Temu, Nathan M. Thielman, Janet P. Bettger, Gerald S. Bloomfield, Alexander T. Limkakeng, and Julian T. Hertz. “Thirty-day outcomes and predictors of mortality following acute myocardial infarction in northern Tanzania: A prospective observational cohort study.” Int J Cardiol 342 (November 1, 2021): 23–28. https://doi.org/10.1016/j.ijcard.2021.08.002.

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Goldberg, Elizabeth M., Kohei Hasegawa, Alexis Lawrence, Jeffrey A. Kline, and Carlos A. Camargo. “Viral Coinfection is Associated with Improved Outcomes in Emergency Department Patients with SARS-CoV-2.” West J Emerg Med 22, no. 6 (October 26, 2021): 1262–69. https://doi.org/10.5811/westjem.2021.8.53590.

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Meltzer, Andrew C., Alexander T. Limkakeng, Nina T. Gentile, Jincong Q. Freeman, Nicole C. Hall, Nataly Montano Vargas, David E. Fleischer, et al. “Risk stratification with video capsule endoscopy leads to fewer hospital admissions in emergency department patients with low-risk to moderate-risk upper gastrointestinal bleed: A multicenter clinical trial.” J Am Coll Emerg Physicians Open 2, no. 5 (October 2021): e12579. https://doi.org/10.1002/emp2.12579.

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Limkakeng, Alexander T., Pratik Manandhar, Alaatin Erkanli, Stephanie A. Eucker, Adam Root, and Deepak Voora. “United States Emergency Department Use of Medications with Pharmacogenetic Recommendations.” West J Emerg Med 22, no. 6 (September 23, 2021): 1347–54. https://doi.org/10.5811/westjem.2021.5.51248.

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Breslin, Adam W., Alexander T. Limkakeng, Elizabeth Silvius, Catherine A. Staton, Chandra Almond, Mary-Beth Joshi, Bartley Adams, et al. “Immune response profiling in patients with traumatic injuries associated with alcohol ingestion.” Clin Transl Sci 14, no. 5 (September 2021): 1791–98. https://doi.org/10.1111/cts.13022.

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