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Alexander Tan Limkakeng Jr., MD, MHS

Director, Acute Care Research
Professor of Surgery
Office: 2301 Erwin Road, Box 3096, Durham, NC 27710
Campus Mail: DUMC 2301 Erwin Road Box 3096, Durham, NC 27710

My personal research interest is finding new ways to diagnose acute coronary syndrome. In particular, I am interested in novel biomarkers and precision medicine approaches to this problem. I also have an interest in sepsis and empirical bioethics. As Vice Chief of Research for the Duke Division of Emergency Medicine, I also work with researchers from many fields spanning global health, innovation, clinical trials, basic discovery, and translational research. The common element is time-sensitive health conditions. I help to oversee a team of research professionals in multicenter emergency department studies funded by the National Institutes of Health, foundations, and industry partners.

Education and Training

  • M.H.S., Duke University, 2012
  • M.D., University of Pennsylvania, 2001

Selected Grants

Publications

Horiuchi, Yu, Nicholas Wettersten, Mitul P. Patel, Christian Mueller, Sean-Xavier Neath, Robert H. Christenson, Nils G. Morgenthaler, et al. “Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction.” Circulation 142, no. 16 (October 20, 2020): 1532–44. https://doi.org/10.1161/CIRCULATIONAHA.120.046682.

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Theiling, B Jason, Kendrick V. Kennedy, Alexander T. Limkakeng, Pratik Manandhar, Alaatin Erkanli, and Stephen R. Pitts. “A Method for Grouping Emergency Department Visits by Severity and Complexity.” West J Emerg Med 21, no. 5 (August 21, 2020): 1147–55. https://doi.org/10.5811/westjem.2020.6.44086.

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Hertz, Julian T., Francis M. Sakita, Godfrey L. Kweka, Alexander T. Limkakeng, Sophie W. Galson, Jinny J. Ye, Tumsifu G. Tarimo, et al. “Acute myocardial infarction under-diagnosis and mortality in a Tanzanian emergency department: A prospective observational study.” Am Heart J 226 (August 2020): 214–21. https://doi.org/10.1016/j.ahj.2020.05.017.

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Peacock, W Frank, Brigitte M. Baumann, E Joy Rivers, Thomas E. Davis, Beverly Handy, Christopher W. Jones, Judd E. Hollander, et al. “Using Sex-specific Cutoffs for High-sensitivity Cardiac Troponin T to Diagnose Acute Myocardial Infarction.” Acad Emerg Med, July 29, 2020. https://doi.org/10.1111/acem.14098.

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Limkakeng, Alexander T., Julian Hertz, Reginald Lerebours, Maragatha Kuchibhatla, James McCord, Adam J. Singer, Fred S. Apple, William F. Peacock, Robert H. Christenson, and Richard M. Nowak. “Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction.” Am J Emerg Med, July 18, 2020. https://doi.org/10.1016/j.ajem.2020.06.072.

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Gerardo, C. J., E. Silvius, S. Schobel, J. Eppensteiner, L. McGowan, A. T. Limkakeng, A. D. Kirk, and E. A. Elster. “ASSOCIATION OF A CYTOKINE RESPONSE NETWORK WITH FUNCTIONAL RECOVERY FROM SNAKEBITE ENVENOMING.” In Toxicon, 182:S15–16, 2020.

Scholars@Duke

Peerapornratana, S., P. Priyanka, S. Wang, A. Smith, K. Singbartl, P. M. Palevsky, L. S. Chawla, et al. “Sepsis-Associated Acute Kidney Disease.” Kidney International Reports 5, no. 6 (June 1, 2020): 839–50. https://doi.org/10.1016/j.ekir.2020.03.005.

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Shah, Nidhi, Chen Chen, Nataly Montano, David Cave, Rebecca Siegel, Nina T. Gentile, Alexander T. Limkakeng, Anita B. Kumar, Yan Ma, and Andrew C. Meltzer. “Video capsule endoscopy for upper gastrointestinal hemorrhage in the emergency department: A systematic review and meta-analysis.” Am J Emerg Med 38, no. 6 (June 2020): 1245–52. https://doi.org/10.1016/j.ajem.2020.03.008.

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Fitzgerald, Robert L., Judd E. Hollander, W Frank Peacock, Alexander T. Limkakeng, Nancy Breitenbeck, E Joy Rivers, André Ziegler, Michael Laimighofer, and Christopher deFilippi. “The 99th percentile upper reference limit for the 5th generation cardiac troponin T assay in the United States.” Clin Chim Acta 504 (May 2020): 172–79. https://doi.org/10.1016/j.cca.2020.01.027.

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Christenson, Robert H., Show-Hong Duh, Fred A. Apple, Richard Nowak, W Frank Peacock, A. T. Limkakeng, Zohrab Bostanian, Amin Mohammad, James McCord, and Christopher R. deFilippi. “Pivotal findings for a high-sensitivity cardiac troponin assay: Results of the HIGH-US study.” Clinical Biochemistry 78 (April 2020): 32–39. https://doi.org/10.1016/j.clinbiochem.2019.10.013.

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