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Vascular Surgery Research Laboratory

Photo of Jeffrey Harold Lawson, MD, PhD

Jeffrey Harold Lawson, MD, PhD

Office: 481 Med Sci Res Bldg, Durham, NC 27710
Campus Mail: Box 2622 Med Ctr, Durham, NC 27710
Phone: 919-681-6432
Fax: 
919-681-1094

The Vascular Surgery Research Laboratory is directed by Jeffrey Lawson, MD, PhD, and is actively pursuing basic, translational, and clinical research activities related to the fields of blood coagulation, vascular biology, and vascular surgery. The laboratory has become a leader in the field of vascular translational research and has successfully developed a number of molecular, cellular, and tissue engineered technologies through translational animal studies to first-in-man clinical trials.

  • Preclinical and clinical evaluation of human tissue engineered blood vessels
  • Venous remodeling after arterial bypass and vascular access creation
  • Human blood coagulation response to trauma and elective surgery¬†

Selected Achievements

The laboratory has been involved in the development, preclinical testing, and first-in-man placement of human tissue engineered blood vessels, which has led to publications in Science and Translational Medicine and the Lancet. Members of the lab have published over 100 papers on the topics of blood coagulation, immunology, vascular remodeling, and vascular access.

Advanced Training

We welcome trainees at all levels, including undergraduate, graduate students, medical students, post-doctoral fellows. and surgical trainees.

Contact Us

James Otto, PhD
jim.otto@dm.duke.edu

Jeffrey H. Lawson, MD, PhD
jeffrey.lawson@duke.edu

Latest Publications

Kirkton, RD, Prichard, HL, Santiago-Maysonet, M, Niklason, LE, Lawson, JH, and Dahl, SLM. "Susceptibility of ePTFE vascular grafts and bioengineered human acellular vessels to infection." The Journal of surgical research 221 (January 2018): 143-151.

Full Text

Zhang, L, Wu, J-H, Otto, JC, Gurley, SB, Hauser, ER, Shenoy, SK, Nagi, K, Brian, L, Wertman, V, Mattocks, N, Lawson, JH, and Freedman, NJ. "Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells." Cardiovascular research 113, no. 13 (November 2017): 1551-1559.

Full Text

Bylsma, LC, Gage, SM, Reichert, H, Dahl, SLM, and Lawson, JH. "Arteriovenous Fistulae for Haemodialysis: A Systematic Review and Meta-analysis of Efficacy and Safety Outcomes." European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 54, no. 4 (October 2017): 513-522. (Review)

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Lawson, JH, Glickman, MH, Jakimowicz, T, Peden, EK, Szmidt, J, Witkiewicz, W, Zubilewicz, T, and Niklason, LE. "Bioengineered Human Acellular Vessels for Dialysis Access: Completed Phase 2 Studies." October 2017.

Full Text