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Laboratory of Neurourology

Photo of Matthew Oliver Fraser, PhD

Matthew Oliver Fraser, PhD

Campus Mail: Box 3452, Durham, NC 27710
Phone: 919-286-0411, extension 5883

Scientific Focus

The Laboratory of Neurourology is headed by Matthew O. Fraser, PhD, and focuses on pelvic visceral function and dysfunction. Dr. Fraser is a classically trained physiologist and a neuroscientist (dual degree PhD). In addition to further elucidating the physiology of pelvic viscera, the laboratory is heavily involved in therapeutic development efforts, including pharmacological, medical devices, cell therapy, and tissue engineering approaches. 

  • Cell therapy for neurogenic bladder
  • Pharmacotherapy for ureteric stent pain, overactive and underactive bladder, and neurogenic bladder secondary to spinal cord injury or traumatic brain injury
  • Neurostimulation therapy for overactive and underactive bladder, and neurogenic bladder secondary to spinal cord injury or traumatic brain injury
  • Pelvic visceral cross-sensitization under normal conditions and following spinal cord injury
  • The evolution of lower urinary tract dysfunction in diabetes mellitus
  • Host responses under different conditions following mesh implantation
  • Tissue engineering of the lower urinary tract

Selected Achievements

  1. Development of a double-lumen catheter for simultaneous isolated isovolumetric bladder pressure and anterograde urethral perfusion pressure recordings.
  2. Development of a Leak Point Pressure measurement method involving acute spinal cord injury to eliminate bladder reflexes while maintaining bladder-to-striated sphincter and bladder-to-smooth muscle urethral spinal reflexes combined with the use of an intravesical pressure clamp and a tilt table.
  3. The use of low-dose intravesical protamine sulfate treatment and physiological KCl concentrations as a non-destructive model for acute bladder pain.
  4. The use of the lipoidal phase of liposomes as a non-toxic vehicle for intravesical delivery of lipophilic drugs.
  5. Developed preparation for recording of urinary bladder and distal colonic smooth muscle and their respective striated sphincteric physiological and pathophysiological interactions underlying pelvic visceral cross-sensitization.
  6. Demonstrated the role of diabetic urethropathy in the development of diabetic cystopathy.

Contact Us

Matthew O. Fraser, PhD
matthew.fraser@duke.edu

Latest Publications

Potts, Bradley A., Danielle J. Degoski, Jillene M. Brooks, Andrew C. Peterson, Dwight E. Nelson, Thaddeus S. Brink, and Matthew O. Fraser. “Timing of sacral neurostimulation is important for increasing bladder capacity in the anesthetized rat..” Am J Physiol Renal Physiol 317, no. 5 (November 1, 2019): F1183–88. https://doi.org/10.1152/ajprenal.00167.2019.

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Cameron, Anne P., Jonathan B. Wiseman, Abigail R. Smith, Robert M. Merion, Brenda W. Gillespie, Catherine S. Bradley, Cindy L. Amundsen, et al. “Are three-day voiding diaries feasible and reliable? Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) cohort..” Neurourol Urodyn 38, no. 8 (November 2019): 2185–93. https://doi.org/10.1002/nau.24113.

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Liu, Alice B., Qian Liu, Claire C. Yang, James W. Griffith, Abigail R. Smith, Margaret E. Helmuth, H Henry Lai, et al. “Patient Characteristics Associated with More Bother from Lower Urinary Tract Symptoms..” J Urol 202, no. 3 (September 2019): 585–91. https://doi.org/10.1097/JU.0000000000000324.

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Peterson, Andrew C., Abigail R. Smith, Matthew O. Fraser, Claire C. Yang, John O. L. DeLancey, Brenda W. Gillespie, John L. Gore, et al. “The Distribution of Post-Void Residual Volumes in People Seeking Care in the Symptoms of Lower Urinary Tract Dysfunction Network Observational Cohort Study With Comparison to Asymptomatic Populations..” Urology 130 (August 2019): 22–28. https://doi.org/10.1016/j.urology.2019.01.069.

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