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Clinical Research

Our clinical and translational research is leading to new therapeutics and vaccines to treat several devastating diseases:

  • Cancer
  • Emerging infections
  • HIV
  • Auto-immune disease
  • Cardiovascular disease 

Research Highlights

  • Dr. Weinhold is principal investigator of the NIH-funded laboratory at Duke responsible for measuring HIV-specific immune responses to candidate AIDS vaccines undergoing phase I/II testing.   
  • Dr. Nair and researchers in her lab invented the RNA transfected dendritic cell-based vaccination approach to stimulate tumor immunity.
  • For the past two decades, Dr. Montefiori's laboratory has served as a national and international resource for standardized assessments of neutralizing antibody responses in preclinical and clinical trials of candidate AIDS vaccines. 

Research Programs

Cancer Therapeutics

Developing novel vaccines and innovative immune therapeutic approaches

Our researchers are developing innovative immune therapeutics and novel vaccination approaches that show promise for treating cancer.

Nair Research Lab
Designs and tests novel vaccines against cancer and invented an immunotherapy approach that has shown sucess in clinical trials

Weinhold Research Lab
Develops innovative immune therapeutic approaches that apply to patients with certain solid tumors

Cardiovascular Biology

Exploring molecular therapeutic approaches in the treatment of cardiovascular disease

Sullenger Research Lab
Developing novel, safe, and effective nucleic acid therapeutics

Vaccines

Investigators in the vaccines program explore a broad range of multidisciplinary approaches to development and testing in the arena of therapeutic strategies for various human cancers and infectious diseases.

Labs

Laboratory for AIDS Vaccine Research and Development (Montefiori Research Lab)
Viral immunology and AIDS vaccine development

Nair Research Lab 
Design and testing of novel vaccines against cancer and viral infections in murine and human systems

Cardiovascular Biology Laboratory
Novel, safe, and effective nucleic acid therapeutics

Tomaras Research Lab 
Investigation of host-pathogen interactions in HIV

Weinhold Research Lab 
Development of innovative immune therapeutic approaches based on pre-clinical analyses of relevant anti-viral and anti-tumor cytotoxic T-lymphocyte reactivities

Faculty

The following individual faculty members also conduct vaccine-related research:

Chin Ho Chen, PhD
Guido Ferrari, MD

Immunology

The immunology program is centered on dendritic cell antigen presentation platforms and an extensive repertoire of immune monitoring technologies to support the development and clinical testing of novel immune-based therapies.

Labs

Laboratory for AIDS Vaccine Research and Development (Montefiori Lab) 
Identifies immunogens that generate broadly cross-reactive neutralizing antibodies against HIV-1 for inclusion in vaccines

Nair Research Lab
Designs and tests novel vaccines against cancer and viral infections in murine and human systems

Parker Research Lab
Focuses on the immune system and its role in biology and disease

Tomaras Research Lab
Works to understand host-pathogen interactions in HIV

Weinhold Research Lab 
Develops innovative immune therapeutic approaches that apply to patients with HIV, emerging infections, and solid tumors

Individual Faculty

The following faculty members also conduct immunology research:

Chin Ho Chen, PhD
Guido Ferrari, MD