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Cardiovascular and Pulmonary Biology Laboratory

Photo of Shu Shiuh-Shi Lin, MD, PhD

Shu Shiuh-Shi Lin, MD, PhD

Office: 4537 Duke South, Blue Zone, Durham, NC 27710
Campus Mail: Box 3392 Med Ctr, Durham, NC 27710
Phone: 919-684-4694
Fax: 
919-681-7524

Scientific Focus

Chronic lung allograft dysfunction (CLAD) is often associated with early ischemia-reperfusion injury and/or repetitive aspiration-related lung injury as a result of gastroesophageal reflux. Dr. Shu Lin’s laboratory has developed an experimental rat model of pulmonary orthotopic transplantation and experimentally induced chronic aspiration that captures the clinical milieu in several important aspects. His ongoing studies have revealed that the development of obliterative bronchiolitis in this model, a major cause of CLAD in patients, is dependent on a three-hit injury involving (a) ischemia-reperfusion injury, (b) alloimmunity, and (c) chronic aspiration.

Dr. Lin also conducts research into factors present in post-industrial society that lead to aberrant immune function. This work, in collaboration with Dr. William Parker at Duke, examines the role of the “human biome”, or life associated with the “ecosystem of the human body”, in regulating immune function in the development and progression of atherosclerosis in a genetically modified mouse model. This ongoing research examines ways in which non-infectious immune dysfunction might be averted by manipulation of the biome, particularly the fauna of the biome.

  • The relationship between chronic lung allograft dysfunction and gastroesophageal relfux
  • The role of mast cells in obliterative bronchiolitis–associated CLAD
  • The effects of the biome on the development of atherosclerosis
  • The effects of gastric fluid on the pulmonary microbiome

Selected Achievements

 

Chronic Aspiration-Induced Lung Injury

By using a rodent model of chronic gastric fluid aspiration, our laboratory has been able to investigate various aspects of chronic aspiration-induced lung injury in non-transplant settings. The associated pathology, the aspirate components necessary to reproduce this injury, and the manner in which the immune profile is shifted are some of the notable topics investigated in this line of work.

 

Obliterative Bronchiolitis

In clinical lung transplantation, gastroesophageal reflux-related chronic aspiration has been linked to chronic lung allograft dysfunction (CLAD) in the pathologic form of obliterative bronchiolitis (OB). Our laboratory has successfully recapitulated this pathology in an experimental model in the rat lung transplant. As a result, we have been able to investigate various issues centered around the development of OB-associated CLAD induced by chronic aspiration. For example, mast cells (as the cell type that is potentially involved in the pathogenesis) and the longer ischemic time (as a more conducive condition in which this pathology occurs) have been examined using this experimental animal model of lung transplantation.

Contact Us

Shu Lin, M.D., Ph.D.
Duke University Medical Center
DUMC Box 2605
Durham, NC 27710, USA
Phone: 919-684-3235
Fax: 919-681-7263
E-mail: shu.lin@duke.edu

Latest Publications

Klinger, RY, James, OG, Borges-Neto, S, Bisanar, T, Li, Y-J, Qi, W, Berger, M, Terrando, N, Newman, MF, Doraiswamy, PM, Mathew, JP, Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study Group, , and Neurologic Outcomes Research Group (NORG), . "18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery." Anesthesiology 128, no. 4 (April 2018): 728-744.

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Beinart, D, Finn, SMB, Scheuermann, U, Holzknecht, ZE, Barbas, AS, Parker, W, and Lin, SS. "Murine model of oropharyngeal gastric fluid aspiration-A new assessment method for intrapulmonary liquid distribution using digital pixel calculation." Experimental lung research 43, no. 9-10 (November 2017): 434-438.

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Smyth, K, Morton, C, Mathew, A, Karuturi, S, Haley, C, Zhang, M, Holzknecht, ZE, Swanson, C, Lin, SS, and Parker, W. "Production and Use of Hymenolepis diminuta Cysticercoids as Anti-Inflammatory Therapeutics." Journal of clinical medicine 6, no. 10 (October 24, 2017).

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Karhausen, JA, Smeltz, AM, Akushevich, I, Cooter, M, Podgoreanu, MV, Stafford-Smith, M, Martinelli, SM, Fontes, ML, and Kertai, MD. "Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery." Anesthesia and analgesia 125, no. 4 (October 2017): 1129-1139.

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