Our lab focuses on the role of the innate immune system in alloreactive T cell activation. The innate immune response is our first line of defense against microbial pathogens. Through a variety of pattern recognition receptors (PRRs), the innate immune system can recognize and respond to pathogen-associated molecular patterns (PAMPs) derived from bacteria, viruses, and fungi. It is now well recognized that the innate immune system also responds to tissue injury through the recognition of damage associated molecular patterns (DAMPS), often using the same PRRs. Intracellular signaling pathways downstream from these receptors lead to the production of inflammatory cytokines and co-stimulatory molecule upregulation that drives the adaptive immune response consisting of T and B cells.
- Cell death and inflammation
- Inflammatory mediators in deceased organ donors
- Mitochondria and inflammation
- NK cell activation for tumor therapy
- Identified a mechanism by which A1AT decreases GvHD following Allo-HSCT. Identified a mechanism of NK cell activation by a heparan sulfate mimetic.
- Demonstrated the role of allospecific regulatory T cells in a mouse cardiac transplant model.
- Developed a novel mouse model of pancreatic ischemia-reperfusion injury.
- Collaborated on rodent thymus transplant project.
- Initiated Duke Abdominal Transplant Repository.
- Identified a plasma and a urine biomarker for acute rejection of kidney transplants.
Basic science research
Todd Brennan, MD