Skip to main content

Innate Immunity in Transplantation Laboratory

Photo of Todd Victor Brennan, MD, MS

Todd Victor Brennan, MD, MS

Office: 330 Trent Dr., Durham, NC 27710
Campus Mail: Box 3512, Durham, NC 27710
Phone: 919-613-6133

Scientific Focus

Our lab focuses on the role of the innate immune system in alloreactive T cell activation. The innate immune response is our first line of defense against microbial pathogens. Through a variety of pattern recognition receptors (PRRs), the innate immune system can recognize and respond to pathogen-associated molecular patterns (PAMPs) derived from bacteria, viruses, and fungi. It is now well recognized that the innate immune system also responds to tissue injury through the recognition of damage associated molecular patterns (DAMPS), often using the same PRRs. Intracellular signaling pathways downstream from these receptors lead to the production of inflammatory cytokines and co-stimulatory molecule upregulation that drives the adaptive immune response consisting of T and B cells.

  • Cell death and inflammation
  • Inflammatory mediators in deceased organ donors
  • Mitochondria and inflammation
  • NK cell activation for tumor therapy

Selected Achievements

  • Identified a mechanism by which A1AT decreases GvHD following Allo-HSCT.  Identified a mechanism of NK cell activation by a heparan sulfate mimetic. 
  • Demonstrated the role of allospecific regulatory T cells in a mouse cardiac transplant model.
  • Developed a novel mouse model of pancreatic ischemia-reperfusion injury.
  • Collaborated on rodent thymus transplant project.
  • Initiated Duke Abdominal Transplant Repository.
  • Identified a plasma and a urine biomarker for acute rejection of kidney transplants.

Advanced Training

Basic science research

Contact Us

Todd Brennan, MD
Todd.Brennan@Duke.edu

Latest Publications

Xu, H, Bendersky, VA, Brennan, TV, Espinosa, JR, and Kirk, AD. "IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (November 14, 2017).

Full Text

Brennan, TV, and Yang, Y. "PD-L1 serves as a double agent in separating GVL from GVHD." The Journal of clinical investigation 127, no. 5 (May 2017): 1627-1630.

Full Text

Chung, J, Ebens, CL, Perkey, E, Radojcic, V, Koch, U, Scarpellino, L, Tong, A, Allen, F, Wood, S, Feng, J, Friedman, A, Granadier, D, Tran, IT, Chai, Q, Onder, L, Yan, M, Reddy, P, Blazar, BR, Huang, AY, Brennan, TV, Bishop, DK, Ludewig, B, Siebel, CW, Radtke, F, Luther, SA, and Maillard, I. "Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands." The Journal of clinical investigation 127, no. 4 (April 2017): 1574-1588.

Full Text

Bracamonte-Baran, W, Florentin, J, Zhou, Y, Jankowska-Gan, E, Haynes, WJ, Zhong, W, Brennan, TV, Dutta, P, Claas, FHJ, van Rood, JJ, and Burlingham, WJ. "Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance." Proceedings of the National Academy of Sciences of the United States of America 114, no. 5 (January 17, 2017): 1099-1104.

Full Text