Education

Recently Awarded Research

Clinical Trials
Division	PI	Title	Sponsor
Cardiovascular & Thoracic	Milano, Carmelo A.	The HeartMate II LVAS Pivotal Study Protocol	Thoratec Corporation
Emergency Medicine	Cairns, Charles B.	Clinical evaluation of the vidas nt-proBNP Assay	bioMerieux, Inc.
Emergency Medicine	Cairns, Charles B.	SHORTness of breath In the Emergency department (SHORTIE)	Biosite
Emergency Medicine	Chandra, Abhinav	ATLAS study	Theravance, Inc.
Emergency Medicine	Chandra, Abhinav	Triage Cardioprofiler Plus MPO	Biosite
Emergency Medicine	Gerardo, Charles J.	Efficacy of Crotaline Fab Antivenom For Copperhead Envenomations	Carolinas Medical Center
General Surgery	Desai, Dev M.	Studies of Pediatric Liver Transplantation (SPLIT)	Emmes Corporation
General Surgery	Kuo, Paul C.	Phase IV Study to Access the Safety and Efficacy of Induction Agents	Astellas Pharma US, Inc.
General Surgery	Kuo, Paul C.	Study of 2 Dose Levels of CP-690,550 Administered Concomitantly with IL-2 Receptor Antagonist Induction Therapy	Pfizer, Inc.
General Surgery	Kuo, Paul C.	Sirolimus versus Cyclosporine when Combined in a Regimen containing Basiliximab,Mycophenolate Mofetil	Wyeth Pharmaceuticals
General Surgery	Lawson, Jeffrey H.	Safety of Vascugel Treatment after the Creation of Arteriovenous Access for Hemodialysis Use	Pervasis Therapeutics, Inc.
General Surgery	Lawson, Jeffrey H.	GRAFTcath Vascular Access System (GVAS) Clinical Study Protocol	GRAFTcath, Inc.
Neuro Oncology	Friedman, Henry S.	The Overall Survival of Primary Glioblastoma Multiforme (GBM) Patients	OncoMethylome Sciences, Inc.
Neuro Oncology	Gururangan, Sridharan	A Phase I trial of capecitabine rapidly disintegrting tablets and concomitant radiation therapy in children	St. Jude Children's Research Hospital
Neuro Oncology	Reardon, David	Phase II Trail of eriotinib plus sirolimus for pateints with recurrent malignant glioblastoma	Genentech, Inc.
Neuro Oncology	Reardon, David	Phase II Study of Gleevec Plus Hydroxyurea Patients with Progressive GBM Receiving EIACDs	Novartis Pharmaceuticals
Neuro Oncology	Reardon, David	A Single-Center, Open-Label, Phase II Safety, Pharmacokinetic and Efficacy Study of Panzem Nanocrystal Colloidal Dispersion Administered Orally to Patients with Recurrent Glioblastoma Multiforme	EntreMed, Inc.
Neuro Oncology	Reardon, David	Phase II Study of Imatinib Mesylate Plus Hydroxyurea for Recurrent/Progressive Meningioma	Novartis Pharmaceuticals Corporation
Neuro Oncology	Reardon, David	Phase I Dose Escalation of Gleevec in Combination with PTK787/ZK 222584 Plus Hydroxyurea	Novartis Pharmaceuticals Corporation
Neuro Oncology	Reardon, David	A Phase I Dose Escalation of Gleevec in Combination with RAD001 Plus Hydroxyurea	Novartis Pharmaceuticals Corporation
Neuro Oncology	Reardon, David	Phase II Gleevec + Hydroxyurea in Low Grade Glioma	Novartis Pharmaceuticals Corporation
Neuro Oncology	Vredenburgh, James J.	Dynamic Contrast-enhanced magnetic resonance imaging with Bevacizumab in combination with Irinotecan for Malignant Glioma	Accelerate Brain Cancer Cure, Inc. Genentech, Inc.
Neuro Oncology	Vredenburgh, James J.	A phase II trial of Zometa (zolodronic acid) to prevent osteoporosis in patients with brain tumors	Novartis Pharmaceuticals Corporation
Orthopaedic Surgery	Blake Boggess	Electrolytes and their relationship to athletic performance	Health Sport, Inc.
Orthopaedic Surgery	Garrett, William E.	Efficacy and Safety of OMS103HP with Vehicle in Patients Undergoing Autograft ACL Reconstruction	Omeros Corporation
Orthopaedic Surgery	Zura, Robert D.	Clinical Efficacy and Cost Implications of Acute BMP-2 Application in Grade IIIB Tibia Fractures	Carolinas Medical Center
Orthopaedic Surgery	Zura, Robert D.	Fixation of Proximal, Extra-articular Tibia and Bicondylar Tibial Plateau Fractures	Synthes U.S.A.
Speech & Hearing	Caves, Kevin M.	Evaluation of Dual Display in Alternative Augmentative Communication (ACC)	Madentec USA, Inc.
Urology	Donatucci, Craig F.	Study to Evaluate the Effects of 5mg Tadalafil and 50mg Sildenafil on Visual Function	Eli Lilly and Company
Urology	Donatucci, Craig F.	Long-term extension trial to assess the safety and sustained efficacy of oral UK-390,957	Pfizer, Inc.
Urology	George, Daniel J.	Intravenous Vinflunine in Patients with Locally Advanced or Metastatic Transitional Cell Carcinoma	Bristol-Myers Squibb
Urology	George, Daniel J.	A Phase 1/2 Dose Escalation Trial of Multiple Doses of MLN2704	Millennium Pharmaceuticals, Inc.
Urology	George, Daniel J.	A Single Arm, Phase II Study of RAD001 in Patients with Metastatic, Hormone-Refractory Prostate Cancer	Novartis Pharmaceuticals Corporation
Urology	George, Daniel J.	A SU011248 TREATMENT PROTOCOL FOR PATIENTS WITH CYTOKINEREFRACTORY METASTATIC RENAL CELL CARCINOMA	Pfizer, Inc.
Urology	Preminger, Glenn M.	The Safety and Effectivess of a Drug-Loaded Percuflex Plus Ureteral Stent	Boston Scientific Corporation
Urology	Robertson, Cary N.	PLUS (PDT for Lower Urinary Tract Symptoms)	QLT Phototherapeutics, Inc.

Research
Division	PI	Title	Sponsor
Cardiovascular & Thoracic	Bowles, Dawn E	Novel AAV Capsids for Delivery to the Heart	American Heart Association
Cardiovascular & Thoracic	Lin, Shu S.	The effects of gastroesophageal reflux-induced chronic aspiration on the development of asthma	Society of American Gastrointestinal Endoscopic Surgeons
Cardiovascular & Thoracic	Lin, Shu S.	The Role of Gastroesophageal Reflux in Pulmonary Allograft Dysfunction	American College of Surgeons
Emergency Medicine	Cairns, Charles B.	Burn Surge Capacity Grant with UNC through OEMS	UNC Chapel Hill
Emergency Medicine	Clem, Kathleen J.	Identification of factors that enhance career satisfaction amont practicing female emergency medicine physicians	American College of Emergency Physicians
Experimental	Chen, Chin-Ho	Small Molecular Inhibition of HIV I Maturation	Vanderbilt University
Experimental	Hui-Wen Lo	Targeting Stat3 as a novel strategy in sensitizing breast cancer to EGFR-targeted therapy	Department of Defense
Experimental	Hui-Wen Lo	Nuclear EGFR signaling network in human cancer	National Institutes of Health
Experimental	Guido Ferrari	Infectious Diseases in Africa: Measurement of Immune Responses	National Institutes of Health
Experimental	Montefiori, David C.	Vaccine immune monitoring consortia (VIMC)	Bill and Melinda Gates Foundation
Experimental	Takahashi, Toku	Effects of Short Chain Fatty Acids on Colonic Motility	National Institutes of Health
Experimental	Weinhold, Kent, J.	Independent study collaboration with Roche	Roche Laboratories, Inc.
Experimental	Weinhold, Kent J.	Center for Aids Research (CFAR)	National Institutes of Health
Experimental	Weinhold, Kent J.	Independent Study Collaboration - Wyeth	Wyeth
General Surgery	Devi, Gayathri R.	Inhibition of regulatory T cells as a novel adjuvant for breast cancer immunotherapy	Department of Defense
General Surgery	Lawson, Jeffrey H.	Tissue Engineered Vessel Implants in Canines	Humacyte, Inc.
General Surgery	Lawson, Jeffrey H.	Genomics of Peripheral Arterial Disease	National Institutes of Health
General Surgery	Lyerly, Herbert K.	Summer on the edge	Burroughs Wellcome Fund
General Surgery	Olson, John JR A.	Auto-Antibodies to the Calcium Sensing Receptor: A Novel Mechanism of Disease in Primary Hyperparathyrodism?	Paget Foundation
General Surgery	Ota, David M.	Support for Specimen Banking in ACOSOG	National Cancer Institute
General Surgery	Pryor, Aurora D.	Step Trocar Hernia Rate in Unclosed Fascial Defects in Bariatric Patients	United States Surgical Corporation
General Surgery	White, Rebekah R.	Prostate Stem Cell Antigen	American Association for Cancer Research
Neuro Oncology	Friedman, Henry S.	Temodar Resistance in CNS Tumors	National Institutes of Health
Neuro Oncology	Reardon, David	Phase I/II studies of sorafenib in combination with eriorinib, tipifamib or temsirolimus in patients	National Cancer Institutite
Neuro Oncology	Vrendenburgh, James L.	Phase II avastin, CPT-11 and temodar for gliomas in treatment of malignant gilomas	Genentech, Inc.
Neurosurgery	Mitchell, Duane A.	In vivo imaging of RNA-modified T cells during adoptive immunotherapy against malignant glioma	DUMC
Neurosurgery	Sampson, John H.	Determination of efficacy of two investigational treatments against intracranial MCF7/18 cells	Johnson & Johnson
Neurosurgery	Sampson, John H.	Reconstitution of Anti-Tumor Immunity in Lymphopenic Hosts With Malignant Gliomas	Brain Tumor Society
Neurosurgery	Serafini, Sandra	Multimodality word-finding in Neurosurgical language mapping	National Institutes of Health
Orthopaedic Surgery	Guilak, Farshid	Integrative repair of the knee meniscus	Arthritis Foundation
Orthopaedic Surgery	Olson, Steven A.	Advanced research studies in the field of orthopaedic surgery	Synthes USA
Orthopaedic Surgery	Ruch, David S.	OREF Prospective Clinical Research Grant	Orthopaedic Research and Education Foundation
Plastic & Reconstructive Surgery	Marcus, Jeffrey R.	The Creation of a Digital "Virtual" Atlas of Pediatric Craniofacial Morphology	Southwestern Society of Plastic & Reconstructive Surgeons
Urology	Dahm, Philipp	Prostate Cancer Project - PCaP	University of North Carolina - Chapel Hill
Urology	Freedland, Stephen J.	Effect of carbohydrate restriction plus radiation to delay prostate cancer growth	Atkins Foundation
Urology	Krupsky, Tracey L.	Caress-Couples' arousal relationship satisfaction survey	American Urological Association
Urology	Polascik, Thomas J.	Trent Foundation Grant	Josiah Charles Trent Memorial Foundation
Urology	Sun, Leon	Optimized Prostate Biopsy Using Mathematical Optimization	University of Pennsylvania