Hui-Wen Lo, PhD, MA, MS

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Associate Professor of Surgery
Department / Division:
Surgery / Surgical Sciences
Address:
103 Research Drive
423 Msrb I
Durham, NC 27710
Office Telephone:
(919) 668-6792
Training:
  • PhD, University of Texas Health Sciences Center at Houston, 2002
  • MA, University of Texas at Austin, 1990
  • MS, University of Texas Medical School at Houston, 1994
Research Interests:
The primary interest of my research program is to better understand the biology of cancerous cells and the molecular mechanisms for tumorigenesis. As deregulated signal transduction pathways are a major signature of aggressive cancers, my research goals are to characterize the nature of cancer signaling pathways, understand the extent they cross-talk/interact, and to use the newly obtained information to facilitate the future development of novel prognostic markers as well as better-rationalized anti-cancer therapy.

Among the known signaling networks that are important for cancer formation, growth and progression, three pathways have attracted much attentions, namely, epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3) and the sonic Hedgehog-GLI1 pathways. Given their significant involvement in various perspectives of cancer biology, they are considered ideal targets for cancer therapeutics. However, monotherapy targeting these pathways has demonstrated limited success. It is, therefore, an urgent task to better understand these signaling pathways to improve their efficacy.



Representative Publications:
  • Han, W; Carpenter, RL; Cao, X; Lo, HW. STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3. Molecular Carcinogenesis. 2013;52:959-969.  Abstract
  • Han, W; Carpenter, RL; Lo, H-W. TGLI1 upregulates expression of VEGFR2 and VEGF-A, leading to a robust VEGF-VEGFR2 autocrine loop and cancer cell growth. 2013;1:28-37.  
  • Cao, X; Geradts, J; Dewhirst, MW; Lo, HW. Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. Oncogene. 2012;31:104-115.  Abstract
  • Carpenter, RL; Lo, HW. Hedgehog pathway and GLI1 isoforms in human cancer. Discovery medicine. 2012;13:105-113.  Abstract
  • Carpenter, RL; Lo, HW. Identification, functional characterization, and pathobiological significance of GLI1 isoforms in human cancers. Vitamins and Hormones: Advances in Research and Applications. 2012;88:115-140.  Abstract
  • Han, W; Lo, HW. Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations. Cancer Letters. 2012;318:124-134.  Abstract
  • Cao, X; Zhu, H; Ali-Osman, F; Lo, HW. EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis. Molecular Cancer. 2011;10:26.  Abstract
  • Lo, HW. EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance. Current molecular pharmacology. 2010;3:37-52.  Abstract
  • Lo, HW. Emerging therapeutic targets and agents for glioblastoma therapy - part I. Anti-Cancer Agents in Medicinal Chemistry. 2010;10:437.  Abstract
  • Lo, HW. Emerging therapeutic targets and agents for glioblastoma therapy--part II. Anti-Cancer Agents in Medicinal Chemistry. 2010;10:511.  Abstract
  • Lo, HW. Nuclear mode of the EGFR signaling network: biology, prognostic value, and therapeutic implications. Discovery medicine. 2010;10:44-51.  Abstract
  • Lo, HW. Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas. Current Cancer Drug Targets. 2010;10:840-848.  Abstract
  • Lo, HW; Cao, X; Zhu, H; Ali-Osman, F. Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. Molecular Cancer Research. 2010;8:232-245.  Abstract
  • Zhu, H; Cao, X; Ali-Osman, F; Keir, S; Lo, HW. EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. Cancer Letters. 2010;294:101-110.  Abstract
  • Zhu, H; Lo, HW. The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases. Current Genomics. 2010;11:238-245.  Abstract
  • Lo, HW; Zhu, H; Cao, X; Aldrich, A; Ali-Osman, F. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. Cancer Research. 2009;69:6790-6798.  Abstract
  • Lo, HW; Cao, X; Zhu, H; Ali-Osman, F. Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clinical Cancer Research. 2008;14:6042-6054.  Abstract
  • Lo, HW; Stephenson, L; Cao, X; Milas, M; Pollock, R; Ali-Osman, F. Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene. Molecular Cancer Research. 2008;6:843-850.  Abstract
  • Lo, HW; Ali-Osman, F. Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance. Current Opinion in Pharmacology. 2007;7:367-374.  Abstract
  • Lo, HW; Hsu, SC; Xia, W; Cao, X; Shih, JY; Wei, Y; Abbruzzese, JL; Hortobagyi, GN; Hung, MC. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Research. 2007;67:9066-9076.  Abstract
  • Lo, HW; Hung, MC. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. British Journal of Cancer. 2007;96 Suppl:R16-R20.  Abstract
  • Hanada, N; Lo, HW; Day, CP; Pan, Y; Nakajima, Y; Hung, MC. Co-regulation of B-Myb expression by E2F1 and EGF receptor. Molecular Carcinogenesis. 2006;45:10-17.  Abstract
  • Lo, HW; Ali-Seyed, M; Wu, Y; Bartholomeusz, G; Hsu, SC; Hung, MC. Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. Journal of Cellular Biochemistry. 2006;98:1570-1583.  Abstract
  • Lo, HW; Hsu, SC; Hung, MC. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. Breast Cancer Research and Treatment. 2006;95:211-218.  Abstract
  • Lo, HW; Hung, MC. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. British Journal of Cancer. 2006;94:184-188.  Abstract
  • Lo, HW; Day, CP; Hung, MC. Cancer-specific gene therapy. Advances in Genetics. 2005;54:235-255.  Abstract
  • Lo, HW; Hsu, SC; Ali-Seyed, M; Gunduz, M; Xia, W; Wei, Y; Bartholomeusz, G; Shih, JY; Hung, MC. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell. 2005;7:575-589.  Abstract
  • Lo, HW; Xia, W; Wei, Y; Ali-Seyed, M; Huang, SF; Hung, MC. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Research. 2005;65:338-348.  Abstract
  • Lee, CM; Lo, HW; Shao, RP; Wang, SC; Xia, W; Gershenson, DM; Hung, MC. Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy. Cancer Research. 2004;64:1788-1793.  Abstract
  • Lo, HW; Antoun, GR; Ali-Osman, F. The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. Cancer Research. 2004;64:9131-9138.  Abstract
  • Wang, SC; Lien, HC; Xia, W; Chen, IF; Lo, HW; Wang, Z; Ali-Seyed, M; Lee, DF; Bartholomeusz, G; Ou-Yang, F; Giri, DK; Hung, MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell. 2004;6:251-261.  Abstract
  • Lo, HW; Ali-Osman, F. Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. Journal of Cellular Biochemistry. 2002;87:103-116.  Abstract
  • Lo, HW; Ali-Osman, F. Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. Chemico-Biological Interactions. 1998;111-112:91-102.  Abstract
  • Lo, HW; Ali-Osman, F. Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements. Journal of Biological Chemistry. 1997;272:32743-32749.  Abstract