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Herbert Kim Lyerly, MD

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Professor of Surgery
Associate Professor of Pathology
Assistant Professor in Immunology
Director, Duke Comprehensive Cancer Center in the School of Medicine
Department / Division:
Surgery / Surg Sci Applied Therapeutics Section
Address:
DUMC 2606
Durham, NC 27710
Office Telephone:
919-681-8350
Fax:
919-681-7970
Training:
  • MD, University of California–Los Angeles David Geffen School of Medicine, 1983
Residency:
  • Surgery, Duke University Medical Center, 1984-1985, 1987-1990
Fellowship:
  • Research, Duke University Medical Center, 1985-1987
Clinical Interests:
Surgical treatment of breast cancer; gene- and immune-based therapy for breast, kidney, lung, colon, and pancreatic cancers
Representative Publications:
  • Lyerly, HK. Quantitating cellular immune responses to cancer vaccines. Seminars in Oncology. 2003;30:9-16.  Abstract
  • Morse, MA; Clay, TM; Colling, K; Hobeika, A; Grabstein, K; Cheever, MA; Lyerly, HK. HER2 dendritic cell vaccines. Clinical Breast Cancer. 2003;3 Suppl 4:S164-S172.  Abstract
  • Morse, MA; Nair, SK; Mosca, PJ; Hobeika, AC; Clay, TM; Deng, Y; Boczkowski, D; Proia, A; Neidzwiecki, D; Clavien, PA; Hurwitz, HI; Schlom, J; Gilboa, E; Lyerly, HK. Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA. Cancer Investigation. 2003;21:341-349.  Abstract
  • Clay, TM; Morse, M; Lyerly, HK. Redirecting cytotoxic T lymphocyte responses with T-cell receptor transgenes. Expert Opinion on Biological Therapy. 2002;2:353-360.  Abstract
  • Keilholz, U; Weber, J; Finke, JH; Gabrilovich, DI; Kast, WM; Disis, ML; Kirkwood, JM; Scheibenbogen, C; Schlom, J; Maino, VC; Lyerly, HK; Lee, PP; Storkus, W; Marincola, F; Worobec, A; Atkins, MB. Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy. Journal of Immunotherapy. 2002;25:97-138.  Abstract
  • Morse, MA; Clay, TM; Lyerly, HK. Current status of adoptive immunotherapy of malignancies. Expert Opinion on Biological Therapy. 2002;2:237-247.  Abstract
  • Morse, MA; Lyerly, HK. DNA and RNA modified dendritic cell vaccines. World Journal of Surgery. 2002;26:819-825.  Abstract
  • Morse, MA; Nair, SK; Boczkowski, D; Tyler, D; Hurwitz, HI; Proia, A; Clay, TM; Schlom, J; Gilboa, E; Lyerly, HK. The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer. International Journal of Gastrointestinal Cancer. 2002;32:1-6.  Abstract
  • Morse, MA; Rizzieri, D; Stenzel, TT; Hobeika, AC; Vredenburgh, JJ; Chao, NJ; Clay, TM; Mosca, PJ; Lyerly, HK. Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants. Stem Cells and Development. 2002;11:659-668.  Abstract
  • Mosca, PJ; Hobeika, AC; Colling, K; Clay, TM; Thomas, EK; Caron, D; Lyerly, HK; Morse, MA. Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. Journal of Leukocyte Biology. 2002;72:546-553.  Abstract
  • Boczkowski, D; Nair, SK; Nam, JH; Lyerly, HK; Gilboa, E. Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells. Cancer Research. 2000;60:1028-1034.  Abstract
  • Li, Y; Bendandi, M; Deng, Y; Dunbar, C; Munshi, N; Jagannath, S; Kwak, LW; Lyerly, HK. Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells. Blood. 2000;96:2828-2833.  Abstract
  • Lyerly, HK; Clay, T; Morse, MA. Optimizing dendritic cell function by genetic modification. Journal of the National Cancer Institute. 2000;92:1198-1199.  Abstract
  • Markert, ML; Hicks, CB; Bartlett, JA; Harmon, JL; Hale, LP; Greenberg, ML; Ferrari, G; Ottinger, J; Boeck, A; Kloster, AL; McLaughlin, TM; Bleich, KB; Ungerleider, RM; Lyerly, HK; Wilkinson, WE; Rousseau, FS; Heath-Chiozzi, ME; Leonard, JM; Haase, AT; Shaw, GM; Bucy, RP; Douek, DC; Koup, RA; Haynes, BF; Bolognesi, DP; Weinhold, KJ. Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection. AIDS Research and Human Retroviruses. 2000;16:403-413.  Abstract
  • Morse, MA; Nair, S; Fernandez-Casal, M; Deng, Y; St Peter, M; Williams, R; Hobeika, A; Mosca, P; Clay, T; Cumming, RI; Fisher, E; Clavien, P; Proia, AD; Niedzwiecki, D; Caron, D; Lyerly, HK. Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer. Journal of Clinical Oncology. 2000;18:3883-3893.  Abstract
  • Mosca, PJ; Hobeika, AC; Clay, TM; Nair, SK; Thomas, EK; Morse, MA; Lyerly, HK. A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. Blood. 2000;96:3499-3504.  Abstract
  • Morse, MA; Coleman, RE; Akabani, G; Niehaus, N; Coleman, D; Lyerly, HK. Migration of human dendritic cells after injection in patients with metastatic malignancies. Cancer Research. 1999;59:56-58.  Abstract
  • Morse, MA; Deng, Y; Coleman, D; Hull, S; Kitrell-Fisher, E; Nair, S; Schlom, J; Ryback, ME; Lyerly, HK. A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen. Clinical Cancer Research. 1999;5:1331-1338.  Abstract
  • Morse, MA; Lyerly, HK; Li, Y. The role of IL-13 in the generation of dendritic cells in vitro. Journal of Immunotherapy. 1999;22:506-513.  Abstract
  • Morse, MA; Vredenburgh, JJ; Lyerly, HK. A comparative study of the generation of dendritic cells from mobilized peripheral blood progenitor cells of patients undergoing high-dose chemotherapy. Stem Cells and Development. 1999;8:577-584.  Abstract
  • Nair, SK; Hull, S; Coleman, D; Gilboa, E; Lyerly, HK; Morse, MA. Induction of carcinoembryonic antigen (CEA)-specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA. International Journal of Cancer. 1999;82:121-124.  Abstract
  • Morse, MA; Lyerly, HK; Gilboa, E; Thomas, E; Nair, SK. Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells. Cancer Research. 1998;58:2965-2968.  Abstract
  • Morse, MA; Zhou, LJ; Tedder, TF; Lyerly, HK; Smith, C. Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha for use in cancer immunotherapy. Annals of Surgery. 1997;226:6-16.  Abstract