: We are evaluating the role of gastroesophageal reflux as a cause of pulmonary allograft dysfunction and immune cell activation. Research is conducted in collaboration with Dr. R. Duane Davis and Dr. Shu S. Lin (Thoracic Surgery Division) in the Department of Surgery and focuses on pulmonary transplantation. 2. Gut immunity
: Research has focused on the promicrobial aspects of the immune system. In collaboration with Dr. Randy Bollinger, we have focused on the model of "immune inclusion" in the gut. Work has led to a determination of the apparent function of the human appendix. 3. Protein folding
: Research has focused on the potential role of amphiphilic α-helical potential in the folding of all proteins, including predominantly β-sheet proteins. We are currently conducting experiments aimed at evaluating the working hypothesis that α-helical "dormant domains" are involved in the folding of β-sheet proteins. 4. The biome depletion theory
: We are investigating the immunological differences between laboratory-raised and wild-raised animals as a probe for differences between humans with and without modern medical care, respectively. This comprehensive approach has turned up unexpected and dramatic differences between the unhygienic and hygienic populations. Such differences likely explain the rising incidence of hyper-immune associated disorders such as allergy and autoimmune disease in countries with modern medical practice. Loss of particular components, including helminths, from the human biome is likely responsible for many of the changes, and it is hoped that this situation can be reversed.