Dennis A. Turner, MD

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Professor of Surgery
Professor of Neurobiology
Department / Division:
Surgery / Neurosurgery
Address:
DUMC 3807
Room 4530, Duke South Blue Zone
Durham, NC 27710
Appointment Telephone:
919-684-6706
Office Telephone:
919-684-6706
Fax:
919-681-8068
Training:
  • MD, Indiana University School of Medicine, 1975
Residency:
  • Neurosurgery, University of Washington Medical Center, 1976-1981
Fellowship:
  • Neurophysiology, Institute for Neurophysiology and University Hospital, University of Oslo (Norway), 1981-1982
Other Training:
  • MA, Neurophysiology, Indiana University, 1971-1973
Clinical Interests:
Movement disorders, stereotactic and functional neurosurgery, complex spine abnormalities, general adult neurosurgery
Research Interests:
Current clinical research interests include clinical trials in Parkinson's disease, Alzheimer's disease, deep brain stimulation for depression, and sensory restoration for development of brain machine interfaces. Clinical treatments include deep brain stimulation, which is now a common procedure for treating Parkinson's disease and tremor. Basic science research interests focus on evaluation of metabolism changes with aging, particularly in response to ischemia and hypoglycemia, as well as epilepsy and seizure mechanisms as functions of both post-lesion injury and aging brain. These basic science interests include new approaches to optical imaging of the brain, cellular understanding of metabolism using direct substrate recordings (ie, oxygen, glucose, lactate) and developing new methods to understand complex interactions between neurons, astrocytes and blood vessels.
Representative Publications:
  • Bartus, RT; Baumann, TL; Siffert, J; Herzog, CD; Alterman, R; Boulis, N; Turner, DA; Stacy, M; Lang, AE; Lozano, AM; Olanow, CW. Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients. Neurology. 2013;80:1698-1701.  Abstract
  • Brocker, DT; Swan, BD; Turner, DA; Gross, RE; Tatter, SB; Koop, MM; Bronte-Stewart, H; Grill, WM. Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease. Experimental Neurology. 2013;239:60-67.  Abstract
  • Birdno, MJ; Kuncel, AM; Dorval, AD; Turner, DA; Gross, RE; Grill, WM. Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation. Journal of Neurophysiology. 2012;107:364-383.  Abstract
  • Galeffi, F; Turner, DA. Exploiting metabolic differences in glioma therapy. Current Drug Discovery Technologies. 2012;9:280-293.  Abstract
  • Hanson, TL; Fuller, AM; Lebedev, MA; Turner, DA; Nicolelis, MA. Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients. The Journal of Neuroscience. 2012;32:8620-8632.  Abstract
  • Shetty, PK; Galeffi, F; Turner, DA. Cellular Links between Neuronal Activity and Energy Homeostasis. Frontiers in Pharmacology. 2012;3:43.  Abstract
  • Shetty, PK; Sadgrove, MP; Galeffi, F; Turner, DA. Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation. Neurobiology of Disease. 2012;45:177-187.  Abstract
  • Galeffi, F; Somjen, GG; Foster, KA; Turner, DA. Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices. Journal of Cerebral Blood Flow and Metabolism. 2011;31:626-639.  Abstract
  • Shetty, PK; Galeffi, F; Turner, DA. Age-Induced Alterations in Hippocampal Function and Metabolism. Aging and Disease. 2011;2:196-218.  Abstract
  • Waldau, B; Clayton, DA; Gasperson, LB; Turner, DA. Analysis of the time course of the effect of subthalamic nucleus stimulation upon hand function in Parkinson's patients. Stereotactic and Functional Neurosurgery. 2011;89:48-55.  Abstract
  • Dorval, AD; Kuncel, AM; Birdno, MJ; Turner, DA; Grill, WM. Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity. Journal of Neurophysiology. 2010;104:911-921.  Abstract
  • Marks, WJ; Bartus, RT; Siffert, J; Davis, CS; Lozano, A; Boulis, N; Vitek, J; Stacy, M; Turner, D; Verhagen, L; Bakay, R; Watts, R; Guthrie, B; Jankovic, J; Simpson, R; Tagliati, M; Alterman, R; Stern, M; Baltuch, G; Starr, PA; Larson, PS; Ostrem, JL; Nutt, J; Kieburtz, K; Kordower, JH; Olanow, CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurology. 2010;9:1164-1172.  Abstract
  • Foster, KA; Margraf, RR; Turner, DA. NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. Neurobiology of Aging. 2008;29:598-613.  Abstract
  • Patil, PG; Turner, DA. The development of brain-machine interface neuroprosthetic devices. Neurotherapeutics. 2008;5:137-146.  Abstract
  • Galeffi, F; Foster, KA; Sadgrove, MP; Beaver, CJ; Turner, DA. Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. Journal of Neurochemistry. 2007;103:2449-2461.  Abstract
  • Lang, AE; Gill, S; Patel, NK; Lozano, A; Nutt, JG; Penn, R; Brooks, DJ; Hotton, G; Moro, E; Heywood, P; Brodsky, MA; Burchiel, K; Kelly, P; Dalvi, A; Scott, B; Stacy, M; Turner, D; Wooten, VG; Elias, WJ; Laws, ER; Dhawan, V; Stoessl, AJ; Matcham, J; Coffey, RJ; Traub, M. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Annals of Neurology. 2006;59:459-466.  Abstract
  • Patil, PG; Turner, DA; Pietrobon, R. National trends in surgical procedures for degenerative cervical spine disease: 1990-2000. Neurosurgery. 2005;57:753-758.  Abstract
  • Patil, PG; Carmena, JM; Nicolelis, MA; Turner, DA. Ensemble recordings of human subcortical neurons as a source of motor control signals for a brain-machine interface. Neurosurgery. 2004;55:27-35.  Abstract
  • Smith-Hammond, CA; New, KC; Pietrobon, R; Curtis, DJ; Scharver, CH; Turner, DA. Prospective analysis of incidence and risk factors of dysphagia in spine surgery patients: comparison of anterior cervical, posterior cervical, and lumbar procedures. Spine. 2004;29:1441-1446.  Abstract
  • Turner, DA; Shetty, AK. Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy. Neurosurgery. 2003;52:632-644.  Abstract
  • Speciale, AC; Pietrobon, R; Urban, CW; Richardson, WJ; Helms, CA; Major, N; Enterline, D; Hey, L; Haglund, M; Turner, DA. Observer variability in assessing lumbar spinal stenosis severity on magnetic resonance imaging and its relation to cross-sectional spinal canal area. Spine. 2002;27:1082-1086.  Abstract
  • Danisa, OA; Turner, D; Richardson, WJ. Surgical correction of lumbar kyphotic deformity: posterior reduction "eggshell" osteotomy. Journal of Neurosurgery. 2000;92:50-56.  Abstract
  • Shetty, AK; Turner, DA. In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor. Developmental Neurobiology. 1998;35:395-425.  Abstract