David H. Harpole Jr., MD

Professor of Surgery
Associate Professor in Pathology
Vice Chief, Division of Surgical Services
Department / Division:
Surgery / Cardiovascular & Thoracic
DUMC 3627
Durham, NC 27710
Appointment Telephone:
Office Telephone:
  • MD, University of Virginia School of Medicine, 1984
  • General Surgery, Duke University Medical Center, 1984-1991
  • Thoracic Surgery, Duke University Medical Center, 1991-1993
  • Thoracic Oncology, Dana Farber Cancer Institute, Harvard Medical School (Massachusetts), 1993-1995
Clinical Interests:
Thoracic oncology; general thoracic surgery; benign and malignant disease of the lung, esophagus, and mediastinum; advanced airway and thoracoscopic surgery; hyperhidrosis palmaris; mesothelioma
Research Interests:
A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.
Representative Publications:
  • Bailey, SH; Bull, DA; Harpole, DH; Rentz, JJ; Neumayer, LA; Pappas, TN; Daley, J; Henderson, WG; Krasnicka, B; Khuri, SF. Outcomes after esophagectomy: a ten-year prospective cohort. The Annals of Thoracic Surgery. 2003;75:217-222.  Abstract
  • Joshi, MB; D'Amico, TA; Harpole, DH. Molecular biologic substaging of stage I NSCLC through immunohistochemistry performed on formalin-fixed, paraffin-embedded tissue. Methods in Molecular Medicine. 2003;75:369-388.  Abstract
  • Kinch, MS; Moore, MB; Harpole, DH. Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003;9:613-618.  Abstract
  • D'Amico, TA; Wong, TZ; Harpole, DH; Brown, SD; Coleman, RE. Impact of computed tomography-positron emission tomography fusion in staging patients with thoracic malignancies. The Annals of Thoracic Surgery. 2002;74:160-163.  Abstract
  • Lau, CL; Moore, MB; Brooks, KR; D'Amico, TA; Harpole, DH. Molecular staging of lung and esophageal cancer. Surgical Clinics of North America. 2002;82:497-523.  Abstract
  • Toloza, EM; Harpole, DH. Intraoperative techniques to prevent air leaks. Chest surgery clinics of North America. 2002;12:489-505.  Abstract
  • Aloia, TA; Harpole, DH; Reed, CE; Allegra, C; Moore, MB; Herndon, JE; D'Amico, TA. Tumor marker expression is predictive of survival in patients with esophageal cancer. The Annals of Thoracic Surgery. 2001;72:859-866.  Abstract
  • D'Amico, TA; Aloia, TA; Moore, MB; Conlon, DH; Herndon, JE; Kinch, MS; Harpole, DH. Predicting the sites of metastases from lung cancer using molecular biologic markers. The Annals of Thoracic Surgery. 2001;72:1144-1148.  Abstract
  • Harpole, DH; Moore, MB; Herndon, JE; Aloia, T; D'Amico, TA; Sporn, T; Parr, A; Linoila, I; Allegra, C. The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001;7:562-569.  Abstract
  • Kelley, MJ; Li, S; Harpole, DH. Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer. Journal of the National Cancer Institute. 2001;93:1886-1888.  Abstract
  • Marom, EM; Aloia, TA; Moore, MB; Hara, M; Herndon, JE; Harpole, DH; Goodman, PC; Patz, EF. Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer. Lung Cancer. 2001;33:99-107.  Abstract